Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

By Shalin H. Naik, P. Sathe, Hae-Young Park, D. Metcalf, Anna I. Proietto, A. Dakic, Sebastian Carotta, Meredith O'Keeffe, Melanie Bahlo, A. Papenfuss and 3 more. Nature Immunology, 2007

910 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/f377676a50a82f8e0ac5da16f6d77c9b25b25789

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In Immunology

1. Florent Ginhoux
2. M. Guilliams
3. Steffen Jung
4. A. Mildner
5. H. Hammad
6. B. Lambrecht
7. Miriam Merad
8. S. Yona

Citations in the corpus

• Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “Both CDPs and cMOPs derive from MDPs and can be distinguished from MDPs by relatively lower c-Kit expression in the case of CDPs (Naik et al., 2007; Onai et al., 2007) and by the loss of CD135 expression in the case of cMOPs (Hettinger et al., 2013). cMOPs give rise to bothmonocyte subsets, the Ly6C”
• Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “Flt3-L / mice have a severe deficit of DCs (Naik et al., 2007; Onai et al., 2007; Liu et al., 2009; Waskow et al., 2008), whereasmonocytes aremissing in mice lackingM-CSF receptor (c-fms or CD115) (Heard et al.”
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “Accordingly, classical short-lived Flt3L-dependent DCs are continuously renewed by on-going hematopoiesis in the BM that feeds the periphery with dedicated DC precursors (Naik et al., 2007; Onai et al., 2007; Karsunky et al., 2003; Waskow et al., 2008).”
• The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “CDPs, which produce DCs but not monocytes (Naik et al., 2007; Onai et al., 2007b), also gave rise to both CD103+ and CD11b+ cDCs (Fig.”
• Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “receptors Flt3 (CD135), M-CSFR (CD115), and low levels of c-Kit (CD117) (42, 43).”
• Overview of the Immune Response (2003, background): “Recent studies of dendritic cell differentiation indicate that both myeloid stem cells and common lymphoid progenitors can give rise to both conventional dendritic cells and plasmacytoid dendritic cells, most likely through a dendritic cell precursor that is defined by its expression of the Fms-like”
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages (2012, methodology): “Finally, at the single cell level, a fraction of cells identified as CDPs lacked pDC potential (Naik et al., 2007), suggesting the need for additional factors in defining progenitors of DC lineages.”
• Tolerogenic dendritic cells (2016, background): “Both cDCs and pDCs are derived from the common DC progenitors (CDPs) in an Flt3dependent manner [21, 22], but the differentiation of each DC subset is driven by different transcription factors (Fig.”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Mice that lack either Flt3 or Flt3L have reduced numbers of MDPs, CDPs, and tissue cDCs and pDCs (25, 55, 95).”
• Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen (2010, background): “In the latter model, it was hard to foresee a scenario whereby exceedingly rare antigen-specific naive T cells, DCs, and the innate cell–producing IL-4 could find each other in right the anatomical context CORRESPONDENCE Bart N. Lambrecht: Bart.lambrecht@ugent.be OR Hamida Hammad: hamida.hammad@ugen”