Tissue-Resident Macrophage Ontogeny and Homeostasis.

By Florent Ginhoux, M. Guilliams. Immunity, 2016

1,570 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/002f8abfddf167def6e91c44696b67bd4631aa00

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. S. Gordon
3. P. Murray
4. M. Locati
5. A. Mildner
6. G. Curtale
7. A. Misharin
8. Klaus Ley

In Neurology

1. A. Mantovani
2. P. Murray
3. S. Gordon
4. Chao Gao
5. Shengdi Chen
6. Yuyan Tan
7. Jingwen Jiang
8. M. Guilliams

Citations in the corpus

• The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “demonstrated that macrophages derived from embryonic yolk sacs were maintained in peripheral tissues by self-renewal, in addition to the macrophages derived from hematopoietic stem cells [28,29].”
• Phagocytosis: An Immunobiologic Process. (2016, background): “During development, macrophages develop from precursors in the yolk sac, fetal liver, and spleen and persist as tissue-resident macrophages in many organs throughout adult life (Ginhoux and Guilliams, 2016).”
• Macrophage Polarization. (2017, background): “In the gut, macrophage turnover is rapid (days to weeks), whereas in the lungs, months to years are needed to replace the embryonic-derived alveolar macrophages (51, 53, 55, 56).”
• Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction (2018, neutral): “Macrophages are specialized mononuclear phagocytes that reside in all tissues from the earliest stages of development, with particularly important roles in the response to injury 3, 4, 5, 6 .”
• Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages (2019, background): “Their origin has been debated extensively during the past years (1, 2).”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “46,47 Thus, primary EMPs, secondary EMP-derived fetal liver monocytes, and HSC-derived fetal liver monocytes contribute to all tissue macrophages, with microglia arising solely from primary EMP.”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “In adult life, in many murine tissues the resident population of mononuclear phagocytes is a mix of cells originating during development and circulating monocytic precursors (2; 14), as illustrated by heart macrophages (15).”
• Developmental and Functional Heterogeneity of Monocytes. (2018, background): “all—have an embryonic origin, while cDC derive from distinct BM precursors (Ginhoux and Guilliams, 2016; Mildner and Jung, 2014).”