Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

By H. Hammad, M. Plantinga, K. Deswarte, P. Pouliot, M. Willart, M. Kool, Femke Muskens, B. Lambrecht. Journal of Experimental Medicine, 2010

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It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI+ DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.

Subfields: Immunology, Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/97bfaf8409993d85c1a22bf22b4ec48c5db5371a

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Citations in the corpus

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion (2014, background): “Previous studies have demonstrated that MHCII-expressing conventional antigen-presenting DCs play a critical role in generating type-2 responses (Hammad et al., 2010; Phythian-Adams et al., 2010).”
Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, background): “DCs, but not macrophages, express CD1a and FcεRI, whereas neither cell type expressed CD209 (DC-SIGN).”