Plasmacytoid Dendritic Cells: Recent Progress and Open Questions
By B. Reizis, A. Bunin, H. Ghosh, Kanako L. T. Lewis, V. Sisirak. Annual Review of Immunology, 2011
621 citations recorded by the source corpus.
Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen presentation capacity, this powerful functionality enables pDCs to orchestrate innate and adaptive immune responses. pDCs combine features of both lymphocytes and classical dendritic cells and display unique molecular adaptations to nucleic acid sensing and IFN production. In the decade since the identification of the pDC as a distinct immune cell type, our understanding of its molecular underpinnings and role in immunity has progressed rapidly. Here we review select aspects of pDC biology including cell fate establishment and plasticity, specific molecular mechanisms of pDC function, and the role of pDCs in T cell responses, antiviral immunity, and autoimmune diseases. Important unresolved questions remain in these areas, promising exciting times in pDC research for years to come.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/fdbd9a2eb343a2cbf072c80f564f529973216a79
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In Immunology
- Taro Kawai
- Shizuo Akira
- F. Quintana
- Miriam Merad
- A. Mortha
- R. Medzhitov
- O. Takeuchi
- Daniel B. Stetson
Citations in the corpus
- The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Human pDCs are characterized as Lin− MHC-II+CD303(BDCA2)+CD304(BDCA4)+ (17), whereas cDCs are characterized as Lin− MHC-II+CD11c+ (258–260), although in humans, CD11c is also expressed on most monocytes and macrophages.”
- Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “TLR9 is involved in recognition of HSV-1, HSV-2, and MCMV (Akira et al., 2006; Blasius and Beutler, 2010; Gilliet et al., 2008; Reizis et al., 2011).”
- Mining the human gut microbiota for immunomodulatory organisms (2017, neutral): “For example, for Tregs and pDCs, a strong correlation existed between the SI and the colon (and other tissues).”
- Tolerogenic dendritic cells (2016, background): “pDCs can efficiently prime CD4 T cell responses and cross-prime CD8 T cell responses and are characterized by the production of high amounts of type I interferon (IFN) upon recognition of foreign nucleic acids [23].”