Wnt3a plays a major role in the segmentation clock controlling somitogenesis.

By A. Aulehla, C. Wehrle, B. Brand-Saberi, R. Kemler, A. Gossler, B. Kanzler, B. Herrmann. Developmental Cell, 2003

615 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f1d394561df9eec2172508ce25bd1c134db251ff

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In Molecular Biology

1. R. Nusse
2. C. Logan
3. Christof Niehrs
4. K. Willert
5. K. Jones
6. Olivier Pourquié
7. I. Thesleff
8. J. Chal

Citations in the corpus

• Towards an integrated view of Wnt signaling in development (2009, background): “For instance, they can result in the stable oscillations that are observed during somitogenesis, when periods of high and low Wnt signaling activity alternate (Aulehla et al., 2003; Aulehla et al., 2008; Suriben et al., 2006), or in the regular spacing of hair follicles in the skin (Sick et al.”
• The Wnt signaling pathway in development and disease. (2004, background): “The Axin2[gene is also a direct Wnt target that is expressed in many sites where Wnt signaling is known to occur (Aulehla et al. 2003, Jho et al. 2002).”
• Making muscle: skeletal myogenesis in vivo and in vitro (2017, background): “Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.”
• Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (2004, background): “It has been shown that, in mice, Axin2 exhibits tissueand stage-specific expression patterns during development (Jho et al. 2002; Aulehla et al. 2003).”
• Biological Physics of the Developing Embryo (2005, neutral): “The FGF8 gradient (along with the coordinated activity of Wnt3A; Aulehla et al., 2003) thus acts as a ‘‘gate,” which, when its low end coincides with a particular phase of the segmentation clock, results in the formation of a boundary (Pourquié, 2003) (Fig.”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “In the vestigial tail (vt) mouse mutant, a hypomorph of Wnt3a, caudal somites are missing (Greco et al., 1996), and oscillating expression of the Wnt target Axin2 is lost (Aulehla et al., 2003).”
• Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. (2003, neutral): “The Somite Oscillator in Chick and Mouse central pacemaking role for Lfng [27, 28] or for Axin2 May Be More Complex [ 30 ].”
• Wnt signaling: is the party in the nucleus? (2006, background): “Whereas oscillation of Notch target genes requires ongoing Wnt signaling, the converse is not true, suggesting that Wnt lies upstream of Notch signaling in the segmentation clock (Aulehla et al. 2003).”