Wnt signaling: is the party in the nucleus?

By K. Willert, K. Jones. Genes & Development, 2006

640 citations recorded by the source corpus.

The Wnt signaling pathway controls cell proliferation and body patterning throughout development. A surprising number of cytoplasmic Wnt regulators (e.g., beta-catenin, Bcl-9/Lgs, APC, Axin) also appear, often transiently, in the nucleus. beta-Catenin is an integral component of E-cadherin complexes at intercellular adherens junctions, but also recruits chromatin remodeling complexes to activate transcription in the nucleus. The APC tumor suppressor is a part of the cytoplasmic beta-catenin destruction complex, yet also counteracts beta-catenin transactivation and histone H3K4 methylation at Wnt target genes. Furthermore, APC coordinates the cyclic exchange of Wnt coregulator complexes at the DNA. These opposing roles of APC and beta-catenin enable a rapid coordination of gene expression and cytoskeletal organization throughout the cell in response to signaling.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8dda624632132181c4e5df8122245bff15cec8dc

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Citations in the corpus

• Wnt signaling in cancer. (2012, background): “The carboxyl terminus of b-catenin is known to recruit numerous chromatin-remodeling subunits, such as set1 and paf1, that mediate the H3K4me3 histone marks associated with highly active genes (Willert and Jones 2006).”