Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.
By Julian Lewis. Current Biology, 2003
744 citations recorded by the source corpus.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/87ed0b5de738c6dc2267807c6b9ed995b2988d50
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In Cell Biology
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Citations in the corpus
- Biological Physics of the Developing Embryo (2005, neutral): “This has led Lewis to propose that juxtacrine signaling by the Notch pathway, usually considered to act in the determination of cell fate (see below), in this case acts to keep cells in the segment-generating growth zone in synchrony (Lewis, 2003).”
- On the Use of the Hill Functions in Mathematical Models of Gene Regulatory Networks (2008, background): “the somitogenesis segmentation clock [6, 7] The Hill function parameters provide a measure of the ligand affinity for the receptor (parameter K in Equation 2.”
- Turing Instability and Turing–Hopf Bifurcation in Diffusive Schnakenberg Systems with Gene Expression Time Delay (2018, background): “In the context of cellular pattern formation, delays play a central role in the generation of spatially coordinated oscillations of gene expression underlying the formation of vertebrate somites [17].”
- Stochastic delay differential equations for genetic regulatory networks (2007, methodology): “Biological experiments have reported the time delays in the transcription and translation in the Hes1 and Her1 genes in mouse and zebrafish, respectively, and these delays have been used in deterministic models to realize oscillations in gene expression levels [4,13,15,17].”