Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.

By Laura Lammi, S. Arte, M. Somer, H. Jarvinen, P. Lahermo, I. Thesleff, S. Pirinen, P. Nieminen. American Journal of Human Genetics, 2004

706 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/0df18e12511c8ee3f9b4c223a592977bf2f5f620

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In Genetics

1. Hans Clevers
2. R. Nusse
3. Pengfei Lu

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. R. Moon
4. Paul Polakis
5. A. D. Kohn
6. Christof Niehrs
7. W. Birchmeier
8. M. Resh

Citations in the corpus

• Colorectal cancer and genetic alterations in the Wnt pathway (2006, background): “Intriguingly, germline mutations in AXIN2 have been suggested as predisposing to colorectal cancer (Lammi et al., 2004).”
• Wnt signaling in cancer. (2012, background): “Axins I and II are also tumor suppressors found mutated in both sporadic cancers, particularly hepatocellar and some colorectal, as well as in some familial cancer syndromes (Lammi et al. 2004; Salahshor and Woodgett 2005; Marvin et al. 2011).”
• WNT and β-catenin signalling: diseases and therapies (2004, background): “Indeed, a Finnish family with severe tooth agenesis and with a history of colorectal cancer was studied recently; positional cloning identified mutations in AXIN2”
• Wnt/beta-catenin signaling in development and disease. (2006, neutral): “Of note, patients with hereditary Axin2 mutations display a predisposition to colon cancer (Lammi et al., 2004).”
• Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “Therefore, the alteration of Wnt and its related gene copy number in cfDNA can be used to diagnose CRC.”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Pa- 992 Cell 169, June 1, 2017 tients with hereditary Axin2 mutations display a predisposition to colon cancer (Lammi et al., 2004).”
• Wnt/β-catenin signaling and disease. (2012, neutral): “Patients with hereditary Axin2 mutations display a predisposition to colon cancer in addition to tooth agenesis (Lammi et al., 2004).”