Inositol phosphatase SHIP1 is a primary target of miR-155

By Ryan M. O’Connell, Aadel A Chaudhuri, D. Rao, David Baltimore. Proceedings of the National Academy of Sciences of the United States of America, 2009

875 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f17c6e23f1df85e562e9d749c357a2e98c002eea

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Citations in the corpus

Metazoan MicroRNAs (2018, background): “, 2011); perturbed function of macrophages and mast cells (O’Connell et al., 2009; Qayum et al., 2016); altered pathology in >60 disease/injury models”
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development (2010, methodology): “Murine stem cell virus (MSCV)-based retroviruses expressing murine miR-155 were prepared as described previously (O’Connell et al., 2009) and used to spin infect freshly isolated WT bone marrow.”
microRNA regulation of inflammatory responses. (2012, background): “Interestingly, hematopoietic reconstitution of mice with bone marrow expressing a small interfering RNA against SHIP1, or genetic deletion of the gene encoding SHIP1, results in a similar hematopoietic phenotype to that caused by sustained expression of miR-155 (29, 36).”
Akt1 controls macrophage response to LPS by regulating microRNAs (2009, background): “MiR155 also targets and suppresses SOCS1, a critical regulator of STAT signaling, in regulatory T cells (Lu et al., 2009) and the inositol phosphatase SHIP1 (O’Connell et al., 2009).”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “Elegant experiments performed independently by two groups have shown that the Src homology 2 domain-containing inositol 5-phosphatase 1 ( SHIP1 ) is the target of miR-155 (Ref”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “Among miRNAs, miR-155 may have particular relevance because its up-regulation in response to inflammatory signals such as microbial components is associated with the hyperactivation of myeloid cells, possibly due to the derepression of phosphatases that negatively regulate transducers of several sig”
Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D. Inositol phosphatase SHIP1 is a primary target of miR-155.”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Recent studies showed that SHIP1 expression is repressed by the human MIR155 microRNA (1154).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “Our group has found that sustained expression of miR-155 can increase immature granulocyte numbers in vivo , and that several of its targets, including SH2-domain-containing inositol-5-phosphatase 1 ( SHIP1 ; also known as INPP5D ) are probably involved in this proces”