Diversity, Mechanisms and Significance of Macrophage Plasticity

By M. Locati, G. Curtale, A. Mantovani. Annual Review of Pathology, 2019

1,847 citations recorded by the source corpus.

Macrophages are a diverse set of cells present in all body compartments. Diversity is imprinted by their different ontogenetic origin (embryonal versus adult bone marrow-derived cells), by the organ context and by activation or deactivation signals from microbial invasion, tissue damage, dismetabolism and polarized adaptive T cell responses. Classic adaptive responses of macrophages include tolerance, priming and a wide spectrum of activation states including M1 or M2 or M2-like. Moreover, macrophages can retain more long term imprinting of microbial encounters (trained innate immunity). Single cell analysis of mononuclear phagocytes in health and disease has added a new dimension to the diversity of macrophage differentiation and activation. Epigenetic landscapes, transcription factors and microRNA networks underlie the adaptability of macrophages to different environmental cues. Macrophage plasticity is an essential component of the diversity of chronic inflammation and its involvement in diverse human diseases, cancer in particular discussed here as a paradigm.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/cd335b98b1c4c353fc08bb29c0acebabbd2c5968

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. C. Garlanda
3. P. Allavena
4. F. Marchesi
5. A. Sica
6. J. Pollard
7. F. Balkwill
8. D. Hanahan

Citations in the corpus

• Macrophages as tools and targets in cancer therapy (2022, background): “and human tumours has revealed a complex scenario of mononuclear phagocyte clusters well beyond the original simplistic M1/M2 classification (see reFs.(4,7)).”