MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development

By Ryan M. O’Connell, D. Kahn, William S. J. Gibson, June L. Round, R. Scholz, Aadel A Chaudhuri, Melissa E. Kahn, D. Rao, David Baltimore. Immunity, 2010

942 citations recorded by the source corpus.

Summary Mammalian non-coding micro RNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammatory disease. Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155−/− mice were highly resistant to experimental autoimmune encephalomyelitis (EAE). miR-155 functions in the hematopoietic compartment to promote the development of inflammatory T cells including the T helper 17 (Th17) cell and Th1 cell subsets. Furthermore, the major contribution of miR-155 to EAE was CD4+ T cell intrinsic, whereas miR-155 was also required for optimum dendritic cell production of cytokines that promoted Th17 cell formation. Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c782075a9d925547b378d2096e26a5cd67647ba6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. David Baltimore
2. D. Rao
3. Ryan M. O’Connell
4. David P. Bartel
5. Luke A. O'Neill
6. Scott M. Hammond
7. Phillip D. Zamore
8. V. Narry Kim

In Immunology

1. Luke A. O'Neill
2. Ryan M. O’Connell
3. D. Rao
4. David Baltimore

In Molecular Biology

1. David Baltimore
2. Ryan M. O’Connell
3. D. Rao
4. David P. Bartel
5. Luke A. O'Neill
6. Scott M. Hammond
7. Phillip D. Zamore
8. Yukihide Tomari

Citations in the corpus

• Metazoan MicroRNAs (2018, background): “…and function of B cells, T cells, and dendritic cells (Rodriguez et al., 2007; Thai et al., 2007; Kohlhaas et al., 2009; Lu et al., 2009; O’Connell et al., 2010; Dunand-Sauthier et al., 2011); perturbed function of macrophages and mast cells (O’Connell et al., 2009; Qayum et al., 2016);…”
• MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “On the other hand, miR-155 is required for the expression of TNF, IL-6, IL-23 and type I IFN”
• microRNA regulation of inflammatory responses. (2012, background): “This has been shown in mouse models of experimental autoimmune encephalomyelitis (EAE), colitis, and collageninduced arthritis (CIA) (34, 50, 51).”