Role of Akt/protein kinase B in metabolism.

By Eileen L. Whiteman, Han Cho, M. Birnbaum. Trends in endocrinology and metabolism, 2002

697 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f14ba620b9837af7c9f4061003a489845225e2ed

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In Molecular Biology

1. D. Komander
2. D. Altomare
3. R. Barnard
4. Christian K. Roberts
5. D. Alessi
6. A. Schulze
7. J. Testa
8. Mary Y. Wu

Citations in the corpus

• SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth (2008, background): “Glucose uptake and induction of glycolysis by Akt have been studied in the context of the metabolic effects of insulin signaling on cellular and organismal levels (Whiteman et al., 2002).”
• Perturbations of the AKT signaling pathway in human cancer (2005, background): “As a cautionary note, it has been suggested that pharmaceutical inhibition of AKT may impact glucose metabolism, largely because of the critical role of AKT in insulin signaling and maintenance of glucose homeostasis (Whiteman et al., 2002).”
• Genome-scale RNAi screen for host factors required for HIV replication. (2008, background): “AKT and PRKAA1 play a highly conserved role in the regulation of cellular energy metabolism, including glucose transport, glycolysis, fatty acid synthesis, and protein synthesis (Whiteman et al., 2002; Rutter et al., 2003).”
• PDK1, the master regulator of AGC kinase signal transduction. (2004, background): “This indicates that PDK1 plays and essential role regulating insulin-induced glucose uptake in adipocytes, consistent with numerous studies indicating that PKB activation is essential for insulin-induced recruitment of GLUT4 to the plasma membrane [56] [57] [58].”
• Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “One of Akt’s many important functions is mediating the metabolic actions of insulin to stimulate glucose transport (688).”
• The PI3K/AKT pathway in obesity and type 2 diabetes (2018, background): “Most of the extracellular glucose is produced in the kidneys and liver, and only the liver acutely responds to insulin by reducing glucose levels [81].”