PDK1, the master regulator of AGC kinase signal transduction.

By A. Mora, D. Komander, D. V. van Aalten, D. Alessi. Seminars in Cell and Developmental Biology, 2004

870 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7bf3572af24de42843e00f7b1898ecf3b95cdfc7

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In Molecular Biology

1. David M. Sabatini
2. K. Guan
3. J. Blenis
4. R. Anjum
5. K. Inoki
6. T. Balla
7. R. DePinho
8. D. Komander

Citations in the corpus

• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “A chief mediator of PtdIns(3,4,5)P3 actions is the protein kinase Akt (also called PKB) that is recruited to the PM by PtdIns(3,4,5)P3 via its PH domain where it gets phosphorylated on Thr308 and Ser473 by PDK1 (1081) and mTORC2 (1830), respectively, leading to its increased kinase activity.”
• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “In response to PI3K activation, PDK1 and the mammalian target of rapamycin (mTOR, acting in the rapamycin-insensitive TORC2 complex) activate Akt via phosphorylation of two key residues, T308 and S473, respectively (Mora et al. 2004; Sarbassov et al. 2005).”
• Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. (2008, background): “The details of how PI3K enhances PDK1 mediated phosphorylation of other substrates such as p70Sk6 or SGK is not clearly understood (see (168)).”
• Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (2008, background): “To determine the function of Sin1 in PKC and Akt regulation, we analysed Sin1 / MEFs.”
• Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models (2011, neutral): “PDK1 No isoforms [114]”
• (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. (2006, background): “The SGK1 kinase consensus sequence has been defined as R-X-R-X-X-(S/T)- , where X stands for any amino acid, R for arginine, and indicates a hydrophobic amino acid (31, 75, 119, 171, 205, 224, 235, 249).”
• The mammalian ovary from genesis to revelation. (2009, background): “Binding of PIP3 leads to activation of PDK1 and subsequent phosphorylation of AKT and other kinases of the AGC family (protein kinases A, G, and C) (183).”
• The activation of Akt/PKB signaling pathway and cell survival (2005, background): “The primary structure of this kinase is similar to other AGC kinase family members, and it has a PH domain at its carboxyl-terminal [30].”
• The nuts and bolts of AGC protein kinases (2010, background): “Specific phosphorylation substrates for AGC kinases include the activation segments of Akt, S6K, SGK, PKC and RSK isoforms by PDK1 (Ref”
• The RSK family of kinases: emerging roles in cellular signalling (2008, background): “PDK1 has been shown to phosphorylate the activation loop of these AGC kinase”
• Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “nase Akt (protein kinase B) and protein kinase C (110).”