Functional atlas of the integrin adhesome

By R. Zaidel-Bar, Shalev Itzkovitz, Avi Ma’ayan, Ravi Iyengar, Benjamin Geiger. Nature Cell Biology, 2007

1,231 citations recorded by the source corpus.

Subfields: Biophysics, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/f1078003a8946fa37b40a7d0f82919328025a58b

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Citations in the corpus

Nanoscale architecture of integrin-based cell adhesions (2010, methodology): “The localization procedure consisted of the following steps: (1) the individual camera images were aligned by applying the similarity transformations determined from previously recorded images of multiple fiducials in each camera, as described above; (2) these three aligned images of each fluorescen”
Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Database mining combined with an extensive literature search recently identified 156 signaling, structural, and adaptor molecules that comprise the ‘‘integrin adhesome’’ (Zaidel-Bar et al. 2007), and more have since been discovered.”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “This adaptation is similar to and likely intertwined with the compensation and plasticity of focal adhesion and other signaling networks during cell invasion (Zaidel-Bar et al., 2007).”
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner (2008, neutral): “Formula (7) says that close to the leading edge, when x = V / k, the F-actin density increases almost linearly: 0 s f x ! " .”
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, background): “Such motifs were previously also found in other signal transduction and directed information-processing networks ( 30 ), indicating that the HPPI2 network with inferred interaction directions shows similar design principles.”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “Transmembrane integrins link the ECM to the cytoskeleton by clustering in specialized submembranous anchoring complexes (focal adhesions), in which they form molecular bridges by binding to actin-associated proteins, such as talin, vinculin, zyxin and paxilli”
The integrin adhesome: from genes and proteins to human disease (2014, neutral): “PtdIns phosphatases (3) Actin regulators (17)”
Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation (2011, background): “Over 150 different proteins are known to associate with focal adhesions making up the 'integrin adhesome”
Collective cell migration in morphogenesis, regeneration and cancer (2009, background): “In scratch wound assays, the leading edge undergoes integrin-mediated binding to extracellular ligands, followed by the recruitment of cytoskeletal adaptor proteins, which include cortactin, paxilin, talin and vinculin, and thereby couples integrins to the actin cytoskeleto”
Physics of adherent cells (2013, background): “Focal adhesions act not only as mechanical linkers that anchor the cell to its substrate, but also as very prominent signaling centers that activate biochemical signaling molecules that diffuse into the cytoplasm and towards the nucleus (Vogel and Sheetz, 2009; Zaidel-Bar et al., 2007).”
Integrin signalling at a glance (2009, background): “In this article, we highlight several key nodes in the network; we refer readers to Zaidel-Bar et al. (Zaidel-Bar et al., 2007) and Liu et al. (Liu et al., 2000) for more information on the many interactions that occur.”
Integrin Structure and Function (2010, background): “Further, the intracellular signals generated lead to the assembly of the FA complex, a large, dynamic multiprotein complex involving over 150 intracellular proteins (Zaidel-Bar et al. 2007).”
Environmental sensing through focal adhesions (2009, background): “An in silico survey of the adhesome network has revealed some interesting features and design principles that apparently govern molecular interactions at the adhesion site”