Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence.

By Coralie Martin, Peter C E Burdon, G. Bridger, J. Gutiérrez-Ramos, T. Williams, S. Rankin. Immunity, 2003

779 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/f0baf5a5acd35c2e80b8882552ad02f9fcf3cc41

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In Immunology

1. Steffen Jung
2. Eric G. Pamer
3. F. Geissmann
4. A. Luster
5. C. Shi
6. C. Varol
7. Caroline L. Sokol
8. C. Rosales

In Oncology

1. Eric G. Pamer
2. A. Luster
3. F. Geissmann
4. Steffen Jung
5. Caroline L. Sokol
6. C. Rosales
7. I. Charo
8. T. Lawrence

Citations in the corpus

• Monocytes give rise to mucosal, but not splenic, conventional dendritic cells (2007, background): “However, unlike senescent neutrophils that return to the BM to die (22), Gr1high monocytes recycle, diff erentiate into Gr1low monocytes, and can return to the blood to further contribute to the peripheral MP pool.”
• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Pharmacologic CXCR2 inhibition in healthy humans, using ozone- or LPSinduced inflammation models [12–15], or in patients with severe asthma [16] or cystic fibrosis (CF) [17] showed that CXCR2 inhibition is safe and decreases neutrophilic inflammation in the airways.”
• Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. (2005, background): “A newly discovered cytokine, ILstart expressing CXCR4 and home back to the bone 23, has been shown to stimulate IL-17 production in T lymphocytes (Aggarwal et al., 2003; Happel et al., marrow (Martin et al., 2003); however, this process is 2003).”
• Inflammatory Resolution: new opportunities for drug discovery (2004, background): “Apoptosis and phagocytosis What is the fate of inflammatory leukocytes after they have carried out their role? There are a number of routes available for the efficient clearance of these cells, including systemic re-circulatio”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “Neutrophils increase their expression of CXCR4 with senescence, which leads to their entry back into the bone marrow, where they ultimately undergo apoptotic cell death (31).”
• Rhythmic modulation of the hematopoietic niche through neutrophil clearance (2013, background): “Multiphoton microscopy of the calvarial BM of live mice injected with DsRed+ neutrophils confirmed that homed neutrophils establish dynamic and frequent interactions with Cell 153, 1025–1035, May 23, 2013 ª2013 Elsevier Inc. 1029 BM-resident macrophages but not CAR cells (Figures 5C and S4A; Movie…”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Thus, re-expression of CXCR4 on neutrophils is thought to encourage “senescent” neutrophils to return to the bonemarrow (Martin et al., 2003).”
• The chemokine system in innate immunity. (2015, background): “CXCR4 may also play an important role in neutrophil elimination; senescent neutrophils up-regulate expression of CXCR4 and this may promote reentry into the BM where they undergo apoptotic cell death (Martin et al. 2003).”
• Monocyte recruitment during infection and inflammation (2011, background): “Granulocytes are retained in the bone marrow by CXCL12-mediated CXCR4 signalling and exit in response to CXCR2 ligands, such as CXCL2 (also known as MIP2) and CXCL1 (also known as KC), which are produced during infectio”