Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury
By Philipp Kruger, M. Saffarzadeh, A. Weber, N. Rieber, M. Radsak, H. von Bernuth, C. Benarafa, D. Roos, J. Skokowa, D. Hartl. PLoS Pathogens, 2015
631 citations recorded by the source corpus.
Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/416f1c5dc89e7779b8bad892ed3723a2fffc704d
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In Immunology
Citations in the corpus
- DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “However, neutrophils can also significantly increase tissue damage by amplifying the inflammatory response and releasing toxic effectors (70).”
- Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…oxygen species (ROS) production, i.e., oxidative burst, is a powerful antimicrobial weapon, and a major component of the innate immune defense against bacterial and fungal infections (Dupre-Crochet et al., 2013; Mocsai, 2013; Paiva and Bozza, 2014; Kruger et al., 2015; Van Acker and Coenye, 2017).”
- Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism (2018, background): “Neutrophils have been linked to immunopathology and tissue damage (Kruger et al., 2015) and represent a high proportion of the immune cells infiltrating the lung early during viral infection (Perrone et al.”
- The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology (2016, background): “It is via these mechanisms, both within the vasculature and after trans-migration into the tissues that neutrophils act as the effectors of organ damage during ECMO [92].”