Rhythmic modulation of the hematopoietic niche through neutrophil clearance
By M. Casanova-Acebes, Christophe Pitaval, Linnea A. Weiss, C. Nombela-Arrieta, Raphäel Chèvre, Noelia A-González, Y. Kunisaki, Dachuan Zhang, Nico van Rooijen, L. Silberstein and 5 more. Cell, 2013
681 citations recorded by the source corpus.
SUMMARY Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady-state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62LLO CXCR4HI neutrophils that have “aged” in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors, and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms, and expand the ascribed functions of neutrophils beyond inflammation.
Subfields: Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/5f820fdfb15ff24aa46f2b1cb5ab8277f67e29b8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Physiology
Citations in the corpus
- Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “These cells have a hypersegmented nucleus and display the phenotype CD62low CD11bhi CD11chi, which is similar to the one described for murine aged neutrophils (Casanova-Acebes et al., 2013; Zhang et al., 2015).”
- Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Intriguingly, homing of senescent neutrophils back to the bone marrow was found to regulate the circadian release of hematopoietic progenitors into the circulation [22].”