FoxO proteins in insulin action and metabolism.

By A. Barthel, D. Schmoll, T. Unterman. Trends in endocrinology and metabolism, 2005

627 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f07b2b0565fcafec580578b125881df4289f9db0

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Citations in the corpus

SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “FOXO proteins are inactivated by the PI3k-Akt/PKB pathway in response to hormonal signaling (32, 120).”
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, neutral): “(112), including metabolism, apoptosis promotion (e.”
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. (2008, background): “This is an essential pathway in protein synthesis and the regulation of cell growth (188); • Phosphodiesterase-3 (PDE3 ), which hydrolyzes cAMP to block the effects of glucagon on gluconeogenesis, glycogenolysis, and lipolysis (189, 190); • BAD, a Bcl2 family member involved in apoptosis (191–193); ”
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. (2007, background): “FoxO transcription factors share a characteristic DNA-binding domain that recognizes the speciﬁc consensus sequence (C/G)(A/T)AAA(C/A)A in the promoters of target genes (Barthel et al., 2005).”
FOXO3A genotype is strongly associated with human longevity (2008, background): “This is consistent with a known role for FOXO as a mediator of the effects of insulin and insulin-like growth factors on diverse physiological functions, including cell proliferation, apoptosis, and metabolism (17, 54).”
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (2006, background): “Among these are proteins implicated in metabolism, cell growth, and proliferation such as GSK3, mTOR, and TSC2, and proteins that play roles in apoptosis such as BAD, ASK1, and the Forkhead family of transcription factors FoxOs (Lawlor and Alessi, 2001).”
Redox regulation of FoxO transcription factors (2015, background): “Akt-induced FoxO phosphorylation (at three sites in FoxO1a, 3a and 4, at two in FoxO6), as elicited upon stimulation of cells with insulin, usually results in FoxO inactivation and nuclear exclusion, resulting in an attenuation of FoxOdependent expression of genes like those coding for glucose 6-pho”
FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “For a more complete description of the role of FOXO transcription factors in metabolism, please refer to Barthel et al. (2005).”