Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

By William L. Holland, S. Summers. Endocrine reviews, 2008

600 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/3d211171ed60377dea627cf6e74f22ddefff91a1

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Citations in the corpus

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance (2009, background): “as TNF- , which is released from adipocytes and elevated in the plasma of type 2 diabetic and obese subjects (5,6).”
Metabolic flexibility in health and disease (2017, neutral): “The cellular mechanisms for insulin resistance have been reviewed extensively (Flier et al., 1979; Holland and Summers, 2008; Shulman, 2004).”
Adiponectin Regulation and Function (2018, positive): “In vitro and in vivo studies in rodents and humans have demonstrated that pharmacological and genetic ablation of enzymes regulating ceramide biosynthesis prevent insulin resistance (104, 106).”
The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity (2010, background): “Ceramide and its glycerol-based counterpart, diacylglycerol (DAG), correlate with impaired insulin action in muscl”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “Similarly, myriosin administered to Zucker diabetic fatty rats reduces tissue ceramide levels, improves glycemia and circulating TG, and ameliorates glucose and insulin intolerance (271, 272).”
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “Notably, exposure to high levels of saturated fatty acids leads to the synthesis and accumulation of toxic lipid metabolites, such as ceramide [145], which has been shown to induce NADPH oxidase-mediated superoxide production and peroxynitrite formation in bovine coronary arterial endothelial cells ”