Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

By A. Belfiore, F. Frasca, G. Pandini, L. Sciacca, R. Vigneri. Endocrine reviews, 2009

1,021 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0e25f8a9e4fe64889b285726bee1b75c72080550

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. (2015, background): “Many tumors, including breast, colon, lung, Tumor stroma IR-A IR-B IGF-1R Tumor cell growth Aromatase IGFBP1/2 Indirect effects of insulin Direct effects of insulin Estrogen Hyperinsulinemia Hyperglycemia βcell failure Dyslipidemia IL-6, IL-1β, TNF-α IL-6, IL-1β, TNF-α Bioavailable estrogen Factors ”
Insulin and its analogs: actions via insulin and IGF receptors (2010, background): “receptors formed by heterologous hemireceptors [1].”
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Also, in contrast to the peripheral tissues, which express predominantly the B isoform (+exon 11) of the IR, the brain expresses predominantly the A isoform (2exon 11), which has a higher affinity for IGF-2 (2).”
Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “In tumors, aberrant signaling leads to changes in the expression of splicing factors, leading to an increase in IR-A expression, and this is speculated to be responsible for at least part of the effects of hyperinsulinemia on oncogenesis [77].”
The insulin and insulin-like growth factor receptor family in neoplasia: an update (2012, background): “The insulin receptor exists in two splice variant isoforms; the 'B' isoform recognizes only insulin, but the 'A' isoform, which is the isoform that is most commonly expressed by tumours, recognizes both insulin and IGFI”