Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

By S. Avecilla, K. Hattori, B. Heissig, Rafael E. Tejada, F. Liao, K. Shido, D. Jin, S. Dias, Fan Zhang, T. Hartman and 9 more. Nature Medicine, 2004

811 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology

View Paper: https://www.semanticscholar.org/paper/ef8bea78eee6ff668829184a09eaf5b7104dd08d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Carmichael
2. Zena Werb
3. D. Lyden
4. D. Scadden
5. Anne Wilson
6. A. Trumpp
7. P. Patterson

In Hematology

1. D. Lyden
2. S. Carmichael
3. Zena Werb
4. D. Scadden
5. Anne Wilson
6. A. Trumpp
7. P. Patterson
8. J. Talmadge

Citations in the corpus

• Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes (2006, background): “One factor that may mediate cross-talk between hematopoietic cytokines and vascular cells is the chemokine stromal-derived factor 1 (SDF-1, also known as CXCL12), which, through interaction with its receptor CXCR4 (also known as CD184), modulates hematopoiesis and angiogenesi”
• The placenta is a niche for hematopoietic stem cells. (2004, background): “…cord blood in huans and other mammals contains an accessible ource for HSCs at term, although the major limitation f the use of human cord blood stem cells in transplanation is their low abundance, being insufficient to proide adequate hematopoietic recovery for adults (Cairo nd Wagner, 1997).”
• The stem-cell niche as an entity of action (2006, background): “The haematopoietic cells known to be regulated in association with marrow vessels are committed progenitor”
• The incredible journey: From megakaryocyte development to platelet formation (2013, background): “…IV, fibronectin, fibrinogen, and von Willebrand factor, which in conjunction with chemokine-mediated interaction of progenitors allow MKs to relocate to a microenvironment that is both permissive and instructive for the late stages of MK maturation and proplatelet formation (Avecilla et al., 2004).”
• Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells (2010, background): “By contrast, expression of other cytokines, such as SDF-1 and FGF-4 (Avecilla et al., 2004), which promote vascular-dependent thrombopoiesis in TPO-deficient mice, favors differentiation of LT-HSCs.”
• Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, positive): “The first evidence illustrating a critical role for SECs in the regulation of hematopoiesis was the finding by our group that revascularization of the BM after myelosuppression fully restored thrombopoiesis in thrombopoietin-deficient mice (Avecilla et al., 2004).”
• Bone-marrow haematopoietic-stem-cell niches (2006, background): “Indeed BMECs constitutively express cytokines such as CXC-chemokine ligand 12 ( CXCL12 ) and adhesion molecules such as endothelial-cell (E)-selectin and vascular cell-adhesion molecule 1 (VCAM1) that are important for HSC mobilization , homing and engraftment”
• A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “These molecules have a role in cellular differentiation and migration within non-neural stem cell niches in the body (Arai et al., 2004; Avecilla et al., 2004).”
• Endothelial cells and VEGF in vascular development (2005, background): “Bone-marrow endothelial cells regulate proliferation and differentiation of more-committed progenitors of the myeloid and megakaryocyte lineage”