A Neurovascular Niche for Neurogenesis after Stroke
By S. Carmichael. Journal of Neuroscience, 2006
897 citations recorded by the source corpus.
Stroke causes cell death but also birth and migration of new neurons within sites of ischemic damage. The cellular environment that induces neuronal regeneration and migration after stroke has not been defined. We have used a model of long-distance migration of newly born neurons from the subventricular zone to cortex after stroke to define the cellular cues that induce neuronal regeneration after CNS injury. Mitotic, genetic, and viral labeling and chemokine/growth factor gain- and loss-of-function studies show that stroke induces neurogenesis from a GFAP-expressing progenitor cell in the subventricular zone and migration of newly born neurons into a unique neurovascular niche in peri-infarct cortex. Within this neurovascular niche, newly born, immature neurons closely associate with the remodeling vasculature. Neurogenesis and angiogenesis are causally linked through vascular production of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1). Furthermore, SDF1 and Ang1 promote post-stroke neuroblast migration and behavioral recovery. These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/6282dfec19b753cb36406b399a6e44706d2ab1ea
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Citations in the corpus
- Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “…is capable of self-repair after insults that cause extensive neuronal death (Arvidsson et al., 2002), and an increasing number of compensatory neurogenesis have also been found in the brain after stroke (Jin et al., 2006; Lin et al., 2015; Ohab et al., 2006; Otero et al., 2012; Tobin et al., 2014).”
- Adult neurogenesis and the olfactory system. (2009, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript migrate to the area of infarct in close association with angiogenic blood vessels in the area (Ohab et al., 2006; Yamashita et al., 2006; Thored et al., 2007).”
- Astrocytes: biology and pathology (2009, background): “Stroke may also induce neurogenesis from periventricular neural progenitor cells that express GFAP [173].”
- Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “In a situation of ischemic injury in murine brain, cells in blood vessels were shown to express SDF-1 and angiopoietin-1, which recruited and supported neural precursors [86].”
- The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus (2008, background): “This role may extend to the neurogenic response of the brain to injuries such as stroke (Ohab et al., 2006).”