The incredible journey: From megakaryocyte development to platelet formation
By K. Machlus, J. Italiano. Journal of Cell Biology, 2013
800 citations recorded by the source corpus.
Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. During maturation, they become polyploid and accumulate massive amounts of protein and membrane. Then, in a cytoskeletal-driven process, they extend long branching processes, designated proplatelets, into sinusoidal blood vessels where they undergo fission to release platelets. Given the need for platelets in many pathological situations, understanding how this process occurs is an active area of research with important clinical applications.
Subfields: Cell Biology, Hematology
View Paper: https://www.semanticscholar.org/paper/d395237fbbf9d3b985dee65f3306072f4bc72c37
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Citations in the corpus
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. (2014, background): “During this process, megakaryocytes transfer components to daughter platelets, including mRNA(2) and microRNA,(3) as well as cytoplasmic organelles, such as granules and mitochondria.(4,5) Platelets are highly abundant in blood where they promote hemostasis.”
- Platelet secretion: From haemostasis to wound healing and beyond (2015, neutral): “megakaryocyte stage [36], but little is known about exact mechanisms of granule sorting and trafficking to their final destination in platelets”
- The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors (2017, neutral): “These events strikingly resembled proplatelet and preplatelet formation from cultured MKs 3,13,14 .”