Gene-expression profile of the ageing brain in mice

By Cheol-Koo Lee, R. Weindruch, Thomas A. Prolla. Nature Genetics, 2000

1,085 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/eed14d630205d36e20dc6385ee184de6a28c143d

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Citations in the corpus

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. (2001, background): “However, genes found to be regulated by aging (Lee et al. 2000) and caloric restriction (Lee et al. 1999) showed biases equal to those from randomly selected subsets of genes.”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Microarrays of aged human and mouse brains extend these findings by showing that genes related to cellular stress and inflammation increase with age while genes related to synaptic function/transport, growth factors, and trophic support decrease (Lee et al., 2000; Lu et al., 2004).”
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, result): “These findings are similar to a previous oligonucleotide array study that found a gene expression profile indicative of inflammation, oxidative stress, and reduced neurotrophic support in the neocortex and cerebellum of aged mice (41) and rats (42).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Furthermore, aging alters gene expression in muscle and brain, but calorie restriction prevents many of these changes (106, 107).”
Calorie restriction--the SIR2 connection. (2005, background): “Consistent with this dea, microarray analysis showed that many genes inolved in managing oxidative stress were upregulated n the aging brain of mice, changes that were less maniest in CR controls (Lee et al., 2000).”
DNA damage-induced alterations in chromatin contribute to genomic integrity and age-related changes in gene expression (2008, positive): “We chose to examine neocortex because age-related gene expression changes have been well characterized in this tissue (Lee et al., 2000; Lu et al., 2004).”
A mixture model approach for the analysis of microarray gene expression data (2002, methodology): “To illustrate the methods that we are proposing, we analyze data described by Lee et al. (2000).”
Oxidants, oxidative stress and the biology of ageing (2000, result): “In contrast to the age-related attenuation in heat-shock protein induction in response to acute stress, two recent studies using complementary DNA microarray analysis to examine global age-associated changes in gene expression in mouse tissues provided evidence that basal expression (that seen in”
Gene regulation and DNA damage in the ageing human brain (2004, background): “The time in life when brain ageing begins is undefine”
Long-term potentiation and memory. (2004, background): “However, in a recent DNA microarray analysis of the aged brain, Prolla and colleagues (316, 500) reported induction of certain IEGs, specifically junB and c-fos.”