E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

By H. Muller, A. Bracken, R. Vernell, M. Moroni, F. Christians, E. Grassilli, Elena Prosperini, Elena Vigo, J. Oliner, K. Helin. Genes & Development, 2001

803 citations recorded by the source corpus.

The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activity of E2F-regulated promoters. We have used high-density oligonucleotide arrays to identify genes in which expression changed in response to activation of E2F1, E2F2, and E2F3. We show that the E2Fs control the expression of several genes that are involved in cell proliferation. We also show that the E2Fs regulate a number of genes involved in apoptosis, differentiation, and development. These results provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ebc1c626bfc219cf0e03c7f8016dc04605cd06b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. K. Helin
2. Richard A. Young
3. A. Bracken
4. J. Bartek
5. J. Lukas
6. Diego Pasini
7. C. Lukas
8. K. Hansen

In Oncology

1. J. Bartek
2. J. Lukas
3. C. Sherr
4. C. Lukas
5. Scott W. Lowe
6. M. Soengas
7. K. Helin
8. Richard A. Young

Citations in the corpus

• GATHER: a systems approach to interpreting genomic signatures (2006, background): “Overlap in genes between the E2F and TGF-beta pathway was previously observed in data from microarray assays (Muller et al., 2001; Young et al., 2003).”
• E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. (2002, background): “This strongly suggests that the E2F family can be grouped into activator (E2F1, E2F2, and E2F3) and repressor (E2F4 and E2F5) subclasses.”
• Apoptosis and melanoma chemoresistance (2003, background): “Furthermore, as indicated below, E2F and p53 can modulate the expression of apoptotic effectors, and heat shock proteins regulate the formation of the apoptosome (Beere and Green, 2001; Muller et al., 2001; Nahle et al., 2002).”
• A model for transmission of the H3K27me3 epigenetic mark (2008, background): “We have previously shown that the E2F transcription factors control expression of EZH2 , EED and SUZ12 , and that they are induced when cells are released from quiescence (G0) by mitogen stimulation and enter the S phase of the cell cycl”
• The INK4a/ARF network in tumour suppression (2001, background): “by inducing genes that encodes S-phase cyclins and cyclin-dependent kinases (CDKs), DNA polymerase-α, enzymes involved in nucleotide metabolism, and several proteins that function at origins of DNA replicatio”
• Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis (2001, background): “Another recent study using DNA microarrays to analyze E2F-induced gene expression also identified DNA replication and cell cycle genes as induced by E2F proteins (15), but this study also identified a large number of additional genes with roles in apoptosis, differentiation, and development, the maj”
• The retinoblastoma tumour suppressor in development and cancer (2002, background): “Although there is accumulating evidence that de-repression of E2F is important in both apoptosis and cell-cycle regulatio”
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis (2005, background): “A similar response was also observed when oestrogen receptor-tagged E2F1 (ref”
• The E2F1–3 transcription factors are essential for cellular proliferation (2001, result): “This view is consistent with recent genome-wide analyses of cell-cycle-regulated genes, where a large fraction of E2F-regulated gene targets were found to encode proteins known to be involved in the progression of cells into G2 and through mitosi”
• The E2F family: specific functions and overlapping interests (2004, background): “Among these are ARF, p73, APAF1, Casp3, Casp7 and several members of the BH3-only family (Irwin et al, 2000; Stiewe and Putzer, 2000; Moroni et al, 2001; Müller et al, 2001; Nahle et al, 2002).”
• Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity (2004, background): “We and others have identified SUZ12 as a target of the E2F transcription factors ( Muller et al, 2001; Weinmann et al, 2001; Bracken et al, 2003).”