Oxidants, oxidative stress and the biology of ageing

By Toren Finkel, Nikki J. Holbrook. Nature, 2000

2,558 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bad3e2ed623b80b010351c9125cd22663b8c4b2e

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Citations in the corpus

The sites and topology of mitochondrial superoxide production (2010, background): “There is considerable evidence both in favour and against the theory (Beckman and Ames, 1998; Finkel and Holbrook, 2000; Golden et al., 2002; Muller et al., 2007; Sanz et al., 2006).”
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling (2013, neutral): “Historically, mROS were thought to be primarily cytotoxic by directly damaging DNA, lipids, and proteins (Finkel and Holbrook, 2000).”
Molecular and Structural Basis for Redox Regulation of β-Actin (2007, background): “This view is further strengthened by observations that a perturbed oxidative balance with increased ROS levels seems to be symptomatic of a number of disease types as well as cellular senescence.(77,78) Overoxidation may have severe consequences, as oxidative damage is surmised to occur in neurodege”
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. (2001, background): “Oxidative stress is also proposed to be involved in the process of aging both by inducing damage to mitochondrial DNA and by other mechanisms [4,5].”
Disorders of bone remodeling. (2011, background): “There is an age-related increase in ROS levels that arises from age-related increases in ROS production and/or a decrease in antioxidants (89, 90).”
Commercial extract of the brown seaweed Ascophyllum nodosum enhances phenolic antioxidant content of spinach (Spinacia oleracea L.) which protects Caenorhabditis elegans against oxidative and thermal stress (2011, background): “Moreover, C. elegans and humans share similar aspects of ageing (Herndon et al., 2002), where oxidative stress is considered to be a major limiting factor in lifespan (Finkel & Holbrook, 2000).”
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “SIRT6 Deﬁciency and Aging-Related Degeneration ROS have been implicated in the pathogenesis of aging (Finkel and Holbrook, 2000).”
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death (2017, positive): “The accumulation of lipid hydroperoxides (LOOH) has long been implicated in cell death and dysfunction, leading to aging, 1,2 the onset and progression of degenerative disease, 3,4 and cancer.”
The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “When there is a decrease in electron transfer, molecular oxygen can capture electrons from Complex III, resulting in superoxide anion formation [128] [137] [138].”
Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. (2006, neutral): “This situation initiates oxidative stress in biological systems, damage to tissues, inflammation, degenerative diseases, and aging (Sohal et al., 2002; Finkel and Holbrook, 2000).”
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “These mutations are pleiotropic and are correlated with resistance to a variety of environmental stresses, including UV radiation, oxidizing conditions, and heat shock (Larsen, 1993; Lithgow et al., 1995; Murakami and Johnson, 1996; Finkel and Holbrook, 2000).”