Gene regulation and DNA damage in the ageing human brain

By Tao Lu, Ying Pan, S. Kao, Cheng Li, Isaac S. Kohane, J. Chan, B. Yankner. Nature, 2004

1,892 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4b8a0d5fe4327b737fef8a901635053f56929fc4

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Citations in the corpus

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States (2018, background): “During human brain aging, certain regions of nuclear DNA are prone to the accumulation of oxidative damage, with promoters of genes involved in synaptic plasticity and mitochondrial function being particularly affected (Lu et al., 2004).”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, positive): “…damage is insuffi cient, then damaged DNA accumulates, especially, in the promoter regions of protein-coding genes, and this can lead to transcriptional disruption of active genes, followed by cellular dysfunction and, ultimately, apoptosis (Hanawalt, 1994; Lu et al., 2004; Roos and Kaina, 2006).”
Functional organization of the transcriptome in human brain (2008, neutral): “dimnames(dat2)[[2]] #[1] "CB_23_ctrl_A" "CB_30_ctrl_A" "CB_31_ctrl_A" "CB_32_ctrl_A" "CB_39_ctrl_A" "CB_40_ctrl_A" "CB_41_ctrl_A" "CB_66_ctrl_A" #[9] "CB_67_ctrl_A" "CB_80_ctrl_A" "CB_81_ctrl_A" "CB_82_ctrl_A" "CB_H104_ctrl_A" "CB_H110_ctrl_A" "CB_H111_ctrl_A" "CB_H115_ctrl_A" #[17] "CB_H117_ctrl_A"”
Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker (2016, background): “At the same time, brain-predicted age has been used to demonstrate protective influences on brain ageing, including meditation (Luders et al., 2016) and increased levels of education and physical exercise (Steffener et al., 2016).”
Mitochondria take center stage in aging and neurodegeneration (2005, background): “Further data favoring the oxidative damage theory of aging comes from a study of gene expression in frontal cortex of humans aged 26 to 106 years.(13) In individuals older than 76 years, there was downregulation of genes involved in synaptic plasticity, vesicular transport, and mitochondrial functio”
Temporal dynamics and genetic control of transcription in the human prefrontal cortex (2011, background): “Genes with significant increases during fetal development are enriched for genes shown to decrease in the ageing corte”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Microarrays of aged human and mouse brains extend these findings by showing that genes related to cellular stress and inflammation increase with age while genes related to synaptic function/transport, growth factors, and trophic support decrease (Lee et al., 2000; Lu et al., 2004).”
DNA damage and its links to neurodegeneration (2014, positive): “…of post-mortem human brain samples as a function of age revealed that genes encoding for critical neuronal functions, including synaptic plasticity, learning, and memory are downregulated after age 40 and concomitantly, the expression of stress response genes is upregulated (Lu et al., 2004).”