The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

By Robert Fredriksson, Malin C. Lagerström, Lars-Gustav Lundin, Helgi B. Schiöth. 2003

2,891 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

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Citations in the corpus

Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs (2020, background): “G-protein coupled receptors (GPCRs) are the largest family of membrane proteins in the human body comprising nearly 800 distinct receptors [1].”
The Molecular Basis of G Protein–Coupled Receptor Activation (2018, background): “Approximately 800 GPCRs are encoded in the human genome (6).”
Computing Highly Correlated Positions Using Mutual Information and Graph Theory for G Protein-Coupled Receptors (2009, background): “On the basis of whole sequence comparison, Fredriksson and coworkers classified human GPCRs into five distinct subfamilies: the rhodopsin family (R, also known as class A), the adhesion and secretin families (A and S, also known as class B), the glutamate family (G, also known as class C), and the f”
Membrane-protein topology (2006, background): “In mammals, this superfamily alone accounts for nearly 5% of all protein-coding gene”
Modern homology modeling of G-protein coupled receptors: which structural template to use? (2009, background): “Taken together, the plots of Figure 6 illustrate two points with respect to multiple-template models of inactive GPCR structures: (1) When a template shares high sequence identity with the target (e.”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “GPCRs are characterized by their seven transmembrane topology and their linkage to heterotrimeric GTPase (G) proteins on their cytosol, and represent the largest class of membrane proteins in the human genome (Figure 4) (Fredriksson et al., 2003).”
Heterotrimeric G protein activation by G-protein-coupled receptors (2008, background): “Based on phylogenetic analysis, human GPCRs can be classified into five main families of receptors: rhodopsin, secretin, glutamate, adhesion and frizzled–taste-2 (Ref”
The structure and function of G-protein-coupled receptors (2009, background): “GPCRs in vertebrates are commonly divided into five families on the basis of their sequence and structural similarity”
Structure-based drug screening for G-protein-coupled receptors. (2012, background): “If this represents a great expansion from only four years ago, it still represents only 4% of the pharmacologically relevant GPCRs, considering that there are approximately 300 non-olfactory GPCRs in the human genome[3].”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “Deorphanization was facilitated by similarity of its sequence to chemokine receptors and localization of human RDC1 to chromosome 2 in the vicinity of CXCR2 and CXCR4 (Fredriksson et al., 2003; Thelen and Thelen, 2008).”
The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes (2005, methodology): “Our strategy was to create HMMs derived from well-characterized groups of GPCRs from our phylogenetic classification of the entire set of GPCRs in the human genome (Fredriksson et al., 2003c).”