Heterotrimeric G protein activation by G-protein-coupled receptors

By W. Oldham, Heidi E. Hamm. Nature reviews. Molecular cell biology, 2008

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The Radical-Pair Mechanism of Magnetoreception. (2016, neutral): “Many signaling cascades involve G proteins (150).”
Crystal Structure of the β2Adrenergic Receptor-Gs protein complex (2011, neutral): “…observed for the α 5-helix, which is displaced 6Å towards the receptor and rotated as the carboxyl terminal end projects into transmembrane core of the β 2 AR. Previous studies using a variety of approaches have demonstrated the important role of the α 5-helix in GPCR-G protein interactions 29,30 .”
Lifting the lid on GPCRs: the role of extracellular loops (2011, background): “This opens a binding crevice for the C-terminal a5 helix of the Ga subunit and G-protein activation (reviewed in Oldham and Hamm, 2008 and Hofmann et al., 2009; Choe et al., 2011; Standfuss et al., 2011; Rasmussen et al., 2011b).”