The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes

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Structure-Function of the G-protein-Coupled Receptor Superfamily (2012, background): “Although all GPCRs are characterized by a similar seven transmembrane (7TM) topology, the five major families of human GPCRs (2, 52) (Figure 1) share very little sequence identity (SI, < 20% in the TM domain) and possess different extracellular N-terminal domains.”
Lifting the lid on GPCRs: the role of extracellular loops (2011, background): “One GPCR classification suggests that in humans there are 15 family B members that share between 30 and 50% sequence homology (Fredriksson and Schiöth, 2005).”
The G protein-coupled receptor subset of the rat genome (2007, background): “The GRAFS families are found in all bilateral species and it has thus been suggested that they arose before the split of nematodes from the chordate lineage [17].”
Anatomical profiling of G protein-coupled receptor expression (2008, unknown): “Although in vivo roles have been defined for many of the approximately 370 nonodorant GPCRs in mice and humans, the expression and function of many such receptors are incompletely characterized, and a significant fraction remain orphans (Fredriksson et al., 2003; Fredriksson and Schioth, 2005; Hill ”