Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states.

By Katsuhiko Hayashi, S. D. S. de Sousa Lopes, Fuchou Tang, K. Lao, M. Surani. Cell Stem Cell, 2008

656 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6c892711ad9b8b1ed87d442af5c72bdaf9d2da72

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In Molecular Biology

Citations in the corpus

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. (2011, neutral): “ESCs cultured in the presence of serum show substantial heterogeneity (Hayashi et al., 2008) and were inadequate for the uniform induction of EpiLCs (data not shown).”
Droplet barcoding for single cell transcriptomics applied to embryonic stem cells (2015, neutral): “…of the pluripotency factors Nanog (Chambers et al. 2007; Kalmar et al. 2009), Rex1/Zfp42 (Singer et al. 2014; Toyooka et al. 2008) and Stella/Dppa3 (Hayashi et al. 2008), have suggested that ES cells fluctuate infrequently between two metastable epigenetic states corresponding to a pluripotent…”
A double take on bivalent promoters. (2013, background): “Conventional mouse ES cell culture requires the presence of serum, and the heterogeneous expression of pluripotency factors and developmental regulators has been partly attributed to serum components (Chambers et al. 2007; Hayashi et al. 2008; Toyooka et al. 2008).”
Epigenetic reprogramming and induced pluripotency (2009, background): “Similarly, ES cells show fluctuations in Nanog (Chambers et al., 2007), Zinc finger protein 42 (Zfp42 or Rex1) (Toyooka et al., 2008) and Stella (Hayashi et al., 2008) expression, which has been correlated with their ability to maintain pluripotency or to differentiate, respectively.”
Targets and dynamics of promoter DNA methylation during early mouse development (2010, neutral): “It is possible that this reflects a strong heterogeneity between embryonic stem cell”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “Characteristics of Mouse Pluripotent States Characteristic Naive Mouse Pluripotent State Primed Mouse Pluripotent State Alternative names Preimplantation inner cell mass-like; mouse ESC-like Post-implantation epiblast-like; mouse epiblast stem cell-like Stem cell types Embryonic stem cells (ESCs); e”