Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

By S. Fagarasan, M. Muramatsu, Keiichiro Suzuki, H. Nagaoka, H. Hiai, Tasuku Honjo. Science, 2002

598 citations recorded by the source corpus.

Subfields: Biotechnology, Complementary and alternative medicine, Endocrinology

View Paper: https://www.semanticscholar.org/paper/ec7e324e55ecc5ccfafd2f3027894593d133feb1

How researchers see this paper

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In Biotechnology

1. A. Cerutti
2. Jeffrey I. Gordon

In Complementary and alternative medicine

1. A. Cerutti

In Endocrinology

1. Ruth E. Ley
2. B. B. Finlay
3. A. Cerutti
4. D. Artis
5. Rob Knight
6. Eran Elinav

Citations in the corpus

• Shifting the balance: antibiotic effects on host–microbiota mutualism (2011, background): “A lack of immunoglobulin genes in the host results in a 100-fold expansion of the microbiota, resulting in hyperplasia of lymphoid follicles; however, antibiotic treatment corrects this respons”
• The Microbiome in Infectious Disease and Inflammation (2012, unknown): “Constitutive NOD1 signaling by PGN from commensal gram-negative bacteria, such as the genus Bacteroides, is required for the induction and maintenance of ILFs (4).”
• The regulation of IgA class switching (2008, methodology): “By using both canonical and alternative T-cell-dependent pathways, Peyer's patches may generate IgA antibodies to control both commensal and pathogenic bacteri”
• The immune system and the gut microbiota: friends or foes? (2010, background): “Likewise, normally harmless members of the microbiota can initiate intestinal inflammation in individuals who cannot mount efficient intestinal humoral response”
• Interleukin-22: immunobiology and pathology (2015, background): “Initial cryptopatch development seems intrinsically regulated, but subsequent post-natal recruitment of B cells may induce formation of ILFs in a microbiota-dependent fashion, as ILFs are absent in mice treated with broad antibiotics to clear the microbial flora (86, 277, 278).”
• Secretory IgA's Complex Roles in Immunity and Mucosal Homeostasis in the Gut (2011, background): “AID knockout mice were shown to have profound increases in the number of non-pathogenic, anaerobic bacteria throughout their small intestines, as well as hyperplasia of isolated lymphoid follicles”
• Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. (2007, unknown): “Broad Spectrum antibiotic treatment of TRUC colitis Mice were treated as described (Fagarasan et al., 2002; Rakoff-Nahoum et al., 2004).”
• Worlds within worlds: evolution of the vertebrate gut microbiota (2008, background): “Furthermore, the adaptive immune system is known to shape community composition in the gut: for example, IgA deficiency leads to altered gut communities in mic”
• IgE in allergy and asthma today (2008, background): “The gastrointestinal mucosa is an abundant source of both IgA and IgE, and can support CSR to both these isotype”
• Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “For example, mice that are deficient in IgA or activation-induced cytidine deaminase ( AID ), and that therefore lack hypermutated IgA, exhibit aberrant expansion of defined commensal specie”
• IgA response to symbiotic bacteria as a mediator of gut homeostasis. (2007, background): “Changes in gut microbial ecology have been docu- mented in mice with immune deficiencies (Fagarasan et al., 2002; Suzuki et al., 2004).”