Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

By D. Artis. Nature reviews. Immunology, 2008

1,162 citations recorded by the source corpus.

Subfields: Endocrinology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/61a894943459e961e433492e2388fa03a67e611a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. J. Turner
2. Emeran A. Mayer
3. F. Powrie
4. K. Maloy
5. Lan Lin
6. James Versalovic
7. P. Hemarajata
8. Jianqiong Zhang

In Infectious Diseases

1. Emeran A. Mayer
2. J. Turner
3. F. Powrie
4. K. Maloy
5. Lan Lin
6. Jianqiong Zhang
7. James Versalovic
8. P. Hemarajata

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. Emeran A. Mayer
6. J. Turner
7. J. R. Kelly
8. F. Powrie

Citations in the corpus

• Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis (2011, neutral): “1d-f, 2).”
• Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus (2011, background): “2131" language="eng" relation="no"> The maintenance of epithelial barrier function at mucosal sites such as the intestine and respiratory tract is critical for limiting exposure to environmental stimuli, commensal bacteria and invading pathogen”
• Intestinal mucosal barrier function in health and disease (2009, background): “Finally, detailed analyses of the interactions between epithelial cells and luminal microorganisms, as well as the intricacies of mucosal immune regulation, have also been recently reviewed elsewher”
• Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, background): “In addition, many adaptive immune responses against commensal, probiotic, and pathogenic bacteria are mediated in mucosal lymphoid follicles that are distributed throughout the GIT and are referred to as the gut-associated lymphoid tissue (GALT) (8) (Fig.”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “IECs, as a barrier between the intestinal lumen and host connective tissues, are continuously subjected to numerous immunologic stimuli [60].”
• Gut feelings: the emerging biology of gut–brain communication (2011, background): “The fact that mucosal immune cells remain immunologically hyporesponsive to commensal bacteria but also maintain their responsiveness to pathogenic organisms, suggests that under physiological conditions, the intestinal immune system recognizes commensal bacteria and elicits basal or tonic signals”
• Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, background): “The total surface of intestinal mucosa is estimated to be >100 m in humans and harbors >80% of all immune cells (Artis, 2008).”
• RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “Such proximity allows the development of a close symbiotic relationship among the cells of the immune system, the intestinal epithelium and the commensal microflor”
• Probiotics and immunity (2009, background): “Probi‐ otics promote intestinal epithelial cell survival, enhance barrier function, and stimulate protective responses from intestinal epithelial cells [14-16] in the case of intestinal epithelial homeostasis.”