Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

By A. Grishok, A. Pasquinelli, D. Conte, Na Li, S. Parrish, I. Ha, D. Baillie, Andrew Fire, Gary Ruvkun, C. Mello. Cell, 2001

2,031 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ec4d9891c6dc9da1e5e6382f68e1295a5f4cf60d

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Citations in the corpus

Computational and experimental identification of C. elegans microRNAs. (2003, background): “elegans) to release the ~22 nt mature miRNAs (Bernstein et al., 2001; Grishok et al., 2001; Hutvagner et al., 2001; Ketting et al., 2001).”
New microRNAs from mouse and human. (2003, background): “Arabidopsis thaliana miR-171, which is also conserved in Nicotiana benthamiana and rice, was shown experimentally to specifically target SCL6-III and SCL-IV mRNAs for degradation (Llave et al. 2002b), indicating that plant miRNAs can act as small interfering RNAs (siRNAs) that guide target RNA cleav”
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application (2010, background): “where it is further processed by the enzyme Dicer to generate the mature ∼22 nt microRN”
Fertile Hypomorphic ARGONAUTE (ago1) Mutants Impaired in Post-Transcriptional Gene Silencing and Virus Resistance (2002, background): “…and ALG-2, has been investigated. rde-1 mutants are defective for RNAi but are morphologically normal (Tabara et al., 1999), whereas alg-1 and alg-2 mutants are impaired in the regulation of small temporal RNAs that control developmental timing but are not defective in RNAi (Grishok et al., 2001).”
The Drosha-DGCR8 complex in primary microRNA processing. (2004, background): “2004) and they are subsequently cleaved by the cytoplasmic RNase III Dicer into ∼22-nt miRNA duplexes (Bernstein et al. 2001; Grishok et al. 2001; Hutvagner et al. 2001; Ketting et al. 2001; Knight and Bass 2001).”
A human snoRNA with microRNA-like functions. (2008, background): “Pre-miRNAs are transported to the cytoplasm, where the RNase III enzyme Dicer cleaves off the loop of the miRNA hairpin, thereby generating a short dsRNA of about 20–25 nucleotides (nt) in length (Bohnsack et al., 2004; Grishok et al., 2001; Hutvá gner et al., 2001; Lund et al., 2004).”
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. (2005, methodology): “…two phases of RNAi was provided by the identification of the Dicer-interacting proteins R2D2 in Drosophila (Liu et al., 2003), RDE-4 in C. elegans (Grishok et al., 2000, 2001, Tabara et al., 2002), and TRBP in humans (Chendrimada et al., 2005), which are required for posttranscriptional gene…”
microRNAs as oncogenes and tumor suppressors. (2007, background): “Once in the cytoplasm, pre-miRNAs are further processed to a short double strand miRNA:miRNA* duplex by Dicer, a second RNase III endonuclease (Grishok et al., 2001; Hutvagner et al., 2001; Ketting et al., 2001).”
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “1Creative Research Center and School of Biological Sciences, Seoul National University, Seoul, Korea 151-742 2These authors contributed equally to this work *Correspondence: narrykim@snu.ac.kr DOI 10.1016/j.cell.2009.08.002”
Processing of intronic microRNAs (2007, background): “…exported to the cytoplasm by exportin-5 (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004), and in the cytoplasm these precursors are cleaved by the cytoplasmic RNase III Dicer (Bernstein et al, 2001; Grishok et al, 2001; Hutvagner et al, 2001; Ketting et al, 2001; Knight and Bass, 2001).”