Processing of intronic microRNAs

By Young‐Kook Kim, V. Narry Kim. EMBO Journal, 2007

873 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/262be74e95fe8c3d76d7a8fff696d0a6fe6e6507

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In Cancer Research

In Molecular Biology

Citations in the corpus

MicroRNA: Biogenesis, Function and Role in Cancer (2010, methodology): “This proposes that the microprocessor has an alternate recognition method from that described with intergenic pre-miRNA processing which is yet to be investigated [94, 99, 100].”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “About half of all currently identified miRNAs are intragenic and processed mostly from introns and relatively few exons of protein coding genes, while the remaining are intergenic, transcribed independently of a host gene and regulated by their own promoters (13, 24).”
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. (2007, positive): “One strand, the active miRNA, is transferred to an Ago complex and guides it to repress fully complementary or seedmatched target transcripts. explicitly from the processing of canonical intronic miRNA genes, whose cleavage by Drosha occurs prior to host intron splicing (Kim and Kim, 2007).”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “, 2005; Baskerville and Bartel, 2005; Li and Carthew, 2005), suggesting that they tend to be cotranscribed at identical rates from the same promoter(s) (Kim and Kim, 2007).”
A construct with fluorescent indicators for conditional expression of miRNA (2008, positive): “This conclusion agrees with a previous study [46].”
Molecular mechanisms of RNA interference (2013, positive): “Before or after they are excised, introns may serve as viable substrates for microprocessor or Dicer, acting as pri- or pre-miRNAs, respectively (42).”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Furthermore, approximately 40% of miRNAs are encoded in the introns of genes (Kim et al., 2009) and therefore some Pol II transcripts are simultaneously pre-mRNAs and pri-miRNAs.”