A human snoRNA with microRNA-like functions.

By Christine Ender, A. Krek, Marc R. Friedländer, M. Beitzinger, L. Weinmann, Wei Chen, S. Pfeffer, Nikolaus Rajewsky, Gunter Meister. Molecules and Cells, 2008

857 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0bbf3d3f6839fc808422f2dca8450f4c1bdc3212

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Citations in the corpus

Origins and Mechanisms of miRNAs and siRNAs (2009, background): “The ACA45 small nucleolar RNA (snoRNA) is a double-hairpin RNA that can be processed by Dicer to generate a 20–22 nt product (Ender et al., 2008).”
MicroRNAs in development and disease. (2011, background): “In addition, miRNAs that are derived from small nucleolar RNA (snoRNA) in various species (163, 260, 528, 592) are processed by Dicer, but do not require Drosha (260).”
The rise of regulatory RNA (2014, background): “Surprisingly, it appears that all snoRNAs from fission yeast to human produce at least 3 different subclasses of small RNAs 117 , one of which has the same size and functions as a miRNA 118 , and another that is similar in size to piRNA 117 .”
Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “Common to all these RNAi-related small RNA pathways is the central role of Argonaute proteins (for review, see Farazi et al. 2008; Hock and Meister 2008).”
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs (2010, background): “ACA36b was already predicted to have a miRNA-like activity that may compare to the miRNA-activity of ACA45 (16) and we provide experimental data for this function in three human cell lines.”
Viruses, microRNAs, and Host Interactions (2010, background): “Some snoRNA (small nucleolar RNA) and tRNA precursors can adopt alternative structures that also mimic pre-miRNAs and give rise to functional miRNAs after Dicer processing (4, 33).”
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. (2009, background): “In addition, it has been recently demonstrated that snoRNAs can produce small RNAs that are processed in a Drosha-independent and Dicer-dependent manner and incorporate into functional Argonaute complexes (Ender et al. 2008).”
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades (2011, result): “Two miRNAs were found to be anti-sense to the known miRNAs hsa-mir-219-2 and hsa-mir-1295, and ﬁve other miRNAs locate to annotated snoRNAs, consistent with previous reports that snoRNAs can be processed into functional small RNAs [e.g. (49,50)].”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Furthermore, pre-miRNAs can be derived from small nucleolar RNAs (snoRNAs) (69) or tRNA precursors (9).”
Metazoan MicroRNAs (2018, background): “Other examples of these chimeric hairpin RNAs include miR-1839, a mammalian miRNA that derives from a hairpin that falls within the ACA45 small nucleolar RNA (snoRNA) (Ender et al., 2008), and miR-1983, a murine miRNA that derives from a hairpin that partially overlaps a tRNA (Babiarz et al.”