p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

By Tongxiang Lin, C. Chao, Shinichi Saito, S. Mazur, M. Murphy, E. Appella, Yang Xu. Nature Cell Biology, 2005

918 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ec3825097fae726fc2e6b4dac0391420acf81cb2

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Citations in the corpus

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, background): “Notably, Nanog expression is downregulated by the tumor suppressor p53 during ESC differentiation (Lin et al., 2005) and is increased in mammospheres from the p53 / mammary epithelium (Figure 3D).”
Blinded by the Light: The Growing Complexity of p53. (2009, background): “…appear in lower organisms (such as flies and worms) that have no clear need for cancer suppression (Derry et al., 2001; Sutcliffe and Brehm, 2004) and are also reflected in its ability to protect mouse embryonic stem cells from DNA damage by inducing their differentiation (Lin et al., 2005).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Although inhibition of TGF-β signalling improves reprogramming by inducing Nanog in mouse cells, it may also promote the mesenchymal-to-epithelial transition, which is required in the early stages of reprogramming of mouse and human fibroblasts to iPS cells (Li et al., 2010; Samavarchi-Tehrani et al”
How is pluripotency determined and maintained? (2007, background): “, 2006) and is repressed by Tp53 (Trp53 – Mouse Genome Informatics) (Lin et al., 2005), Gcnf (Nr6a1 – Mouse Genome Informatics) (Gu et al.”
Epigenetic reprogramming and induced pluripotency (2009, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. (2008, background): “The ES cells have previously been shown to be very sensitive to genotoxic agents (Lin et al., 2005; Xu et al., 2006).”
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? (2017, background): “Importantly, there is evidence that p53 activation and expression may occur without necessarily resulting in apoptosis or senescence, as has been observed in stem cells, where p53 activation may drive differentiation rather than exerting antiproliferative effects.(105) Finally, dramatic differences ”
Immunogenicity of induced pluripotent stem cells (2011, positive): “Therefore, similarly to that in mouse ESCs (Lin et al., 2005), one important role of p53 in maintaining genomic stability in hESCs could be to suppress Nanog expression after DNA damage, leading to the differentiation of DNA damaged hESCs and, thus, maintaining the genomic stability in the…”