How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
By B. Aubrey, G. Kelly, Ana Janic, Marco J. Herold, A. Strasser. Cell Death and Differentiation, 2017
945 citations recorded by the source corpus.
Subfields: Biotechnology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/0d30b8602ec6087bff752525a6a1e1b16d456830
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In Molecular Biology
In Oncology
Citations in the corpus
- Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “p53 is also thought to regulate mitochondrial apoptosis through a transcription-independent pathway.(33) p53 binds physically to anti-apoptotic proteins (Bcl-2, Bcl-xL and Mcl-1), thereby indirectly inducing apoptosis.”
- Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “The p53 protein, a notable tumor suppressor, plays a principal role in the regulation of cell cycle arrest, cell differentiation, cell metastasis, and apoptosis.(149) In response to cellular stress, p53 is activated and then exerts its transcriptional regulatory function to influence the level of Bc”