Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

By Louis Vermeulen, F. D. S. E. Melo, M. V. D. Heijden, K. Cameron, J. Jong, Tijana Borovski, J. Tuynman, M. Todaro, C. Merz, H. Rodermond and 5 more. Nature Cell Biology, 2010

1,859 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2cb1d074a063b021c658495f5d58566e55872d11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. E. Batlle
3. R. Nusse
4. Zena Werb
5. V. Plaks
6. J. Massagué
7. W. Birchmeier
8. J. Dick

In Oncology

1. Zena Werb
2. V. Plaks
3. J. Massagué
4. Hans Clevers
5. Niwen Kong
6. J. Dick
7. Antonija Krešo
8. E. Batlle

In Pathology and Forensic Medicine

1. R. Nusse
2. W. Birchmeier
3. Hans Clevers
4. J. Massagué

Citations in the corpus

• The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, background): “A recent report demonstrates that tumor cells grown in vitro as colonospheres display different amounts of b-catenin/Tcf signaling that, in turn, regulate the expression of stem cell or differentiation markers (Vermeulen et al., 2010).”
• Evolution of the cancer stem cell model. (2014, background): “In addition to miRNA, the use of reporter assays that measure cellular signaling pathway activity, such as the Wnt reporter (Vermeulen et al., 2010), can be used as alternative means of measuring distinct cellular fractions that may segregate T-IC and non-T-IC.”
• CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. (2011, background): “Given that Wnt signals have been shown to be activated in stem-like cancer cells (Vermeulen et al., 2010), we assume that CD44 fraction contains more stem-like cells than CD44 fraction.”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “Canonical WNT is a major pathway that regulates CSCs and induces stemness in colon and other cancers (Vermeulen et al., 2010; He et al., 2004).”
• Cancer stem cells: an evolving concept (2012, background): “The co-culture resulted in the activation of WNT pathway signalling in the colon cell”
• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014, background): “For example, hepatocyte growth factor from stromal fibroblasts potentiates WNT/b-catenin signaling to enhance the stem cell potential of colorectal cancer cells (Vermeulen et al., 2010).”
• Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “For example, the separation of live cancer cells based on functional measures, such as signaling pathway activation (Vermeulen et al., 2010), might reduce phenotypic variability among tumorigenic cells.”