Real-time imaging reveals the single steps of brain metastasis formation

By Y. Kienast, L. Baumgarten, Martin Fuhrmann, W. Klinkert, R. Goldbrunner, J. Herms, F. Winkler. Nature Medicine, 2010

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “Imaging studies show that circulating tumour cells actively transmigrate through holes in the vessel wall, after which they associate with remodelling vessel”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, positive): “Arrest at branches in blood vessels in the brain, with subsequent extravasation and metastasis formation, has been observed by intravital microscopy in a mouse mode”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “Consistent with this idea, the outgrowth of dormant DTCs in the brain also seems to be dependent on angiogenesis (Kienast et al., 2010).”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “Like cells in primary tumors, cells in metastases also proliferate, invade, and enter blood vessels, leading to secondary metastasis (Kienast et al., 2010; Armstrong et al., 2011; Hou et al., 2011).”
Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer (2010, neutral): “Diffuse/infiltrative lesions may arise in part through perivascular tumor spread via blood vessel co-option (67, 68).”