The microenvironmental landscape of brain tumors
By D. Quail, J. Joyce. Cancer Cell, 2017
1,561 citations recorded by the source corpus.
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
Subfields: Genetics, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/163aa07d2a108d6093d1adb865647e5fae05df94
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In Genetics
Citations in the corpus
- Functional morphology of the blood-brain barrier in health and disease (2018, positive): “Studies following VEGF monotherapy or combined VEGF/Ang-2 targeting in preclinical GBM models demonstrated a more normalised vasculature [106, 110].”
- Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “Although CNS is frequently considered an immuneprivileged site, the functional lymphatic vasculature (in dural meningeal membrane surrounding the brain) and the permeable brain–blood barrier (BBB) could serve as a gateway for signals transmission, thereby suggesting a role of immune cells in CNS dur”
- Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells (2020, background): “Beyond tumor cell-intrinsic effects, this may be attributed in part to immune-suppressive components of the brain TME, including tumor-associated macrophages (TAMs), which have emerged as prominent players in brain cancers (Gutmann and Kettenmann, 2019; Quail and Joyce, 2017).”
- Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021, background): “Glioma recurrence or malignant progression occurs likely for several reasons: (1) infiltrative tumor cells cannot be completely removed by neurosurgical resection [9,10]; (2) residual tumor cells cannot be effectively suppressed by limited postoperative treatment options [3,11,12]; (3) multiple lesi”