The colorectal microRNAome.

By Jordan M. Cummins, Yiping He, R. Leary, R. Pagliarini, L. Diaz, T. Sjoblom, Omer Barad, Z. Bentwich, A. Szafranska, E. Labourier and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

999 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e8e2ae9237eee41e504b5b1ef115bb3c74fb3847

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Citations in the corpus

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, methodology): “2) is commonly reported in miRNA cloning studies but generally dismissed with either the sequence matching the miRBase record or the most frequently observed isomiR chosen as a reference sequence (Cummins et al. 2006; Ruby et al. 2006; Landgraf et al. 2007).”
MicroRNA expression profiling in prostate cancer. (2007, result): “The data agree with the previously published miRNA profiling studies, most of which have shown downregulation of miRNAs to be more common than up-regulation in cancer (9, 10 , 16, 29).”
miR-19 is a key oncogenic component of mir-17-92. (2009, methodology): “…luciferase constructs that contain either the wild-type or the mutated PTEN 3 9 UTR were each transfected into the Dicer-deficient Hct116 cells (Cummins et al. 2006), together with a Renilla luciferase construct for normalization control, and 50 nM miRNA mimics for mir-17 , mir-18 , miR-19b ,…”
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence (2008, positive): “To confirm these results, we transfected wild-type and fully mutated Dicer into two cell lines—the wild-type HCT116 human colorectal cancer cell line and a version of this cell line with targeted disruption of Dicer exon 5, which has the effect of lowering total intracellular mature miRNA concentrat”
Serum MicroRNAs Are Promising Novel Biomarkers (2008, background): “Although the total number of microRNAs remains controversial [4,10,11] and the roles of specific microRNAs are only beginning to be defined, microRNA expression analyses indicate that diverse tumors display microRNA expression profiles (for mature and/or precursor microRNAs) significantly different ”
A mammalian microRNA expression atlas based on small RNA library sequencing. (2007, methodology): “deep-sequencing technologies (Berezikov et al., 2006a, 2006b; Cummins et al., 2006; Kloosterman et al., 2006a) or specialized small RNA isolation and cloning procedures (Bentwich et al.”
mir-29 regulates Mcl-1 protein expression and apoptosis (2007, background): “For example, mir-29 is also downregulated in aggressive chronic lymphocytic leukemia, colon and breast cancer (Calin et al., 2005; Cummins et al., 2006; Yanaihara et al., 2006).”
Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression (2007, methodology): “These lines have homozygous disruption of the Dicer helicase domain and show reduced levels of many endogenous miRNAs (15).”
Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “Alternatively, the induced species may be the result of a catalytic activity of Argonautes upstream of target cleavage in the RNAi pathway, as has been suggested for Argonaute 2 (Diederichs and Haber 2007; O'Carroll et al. 2007 ).”
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype (2007, background): “Subsequently, a number of studies, using a range of techniques, including miRNA cloning, quantitative PCR, microarrays and bead-based flow cytometric miRNA expression profiling [53-56], demonstrated that miRNA expression is deregulated in many human cancers.”
Moderated statistical tests for assessing differences in tag abundance (2007, background): “Availability: An R package can be accessed from http://bioinf.wehi. edu.au/resources/ Contact: smyth@wehi.edu.au Supplementary information: http://bioinf.wehi.edu.au/resources/”