A mammalian microRNA expression atlas based on small RNA library sequencing.

By Pablo Landgraf, M. Rusu, R. Sheridan, A. Sewer, Nicola Iovino, Alexei Aravin, S. Pfeffer, A. Rice, A. Kamphorst, Markus Landthaler and 41 more. Cell, 2007

3,843 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/94c518caaa826159110f1d9fe7d79b88860f4a1e

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Citations in the corpus

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy (2011, neutral): “Because of its elevated levels in many different cancer”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “miR-10a was found to be highly expressed in kidney, muscle, lung, and liver of mice [119].”
miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments (2009, background): “This is an expensive and timeconsuming procedure, and as a consequence, relatively little expression data is currently available [see (6) for a microRNA expression atlas].”
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ (2011, background): “However, to our knowledge, no report has yet identified the function of miR-29 in the regulation of the immune response, except for two reports on the expression profile of miR-29 in T cell”
The biochemical basis of microRNA targeting efficacy (2018, methodology): “To test how well the CNN-predicted relative Kd values enabled our approach to be generalized to other miRNAs and another cell type, we generated 12 miRNA-transfection datasets in HEK293FT cells, choosing miRNAs that were not appreciably expressed in HEK293 cells (44) and that had not been used in an”
Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. (2011, background): “Although a previous classical approach of cloning has partially revealed miRNA expression profile in a panel of mammalian tissues and cell types (Landgraf et al., 2007; Basso et al., 2009), low throughput with low sensitivity and poor resolution makes these approaches unlikely to define miRNome.”
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, background): “Direct sequencing also offers the potential to detect variation in mature miRNA length, as well as enzymatic modification of miRNAs such as RNA editing (Kawahara et al. 2007) and 3 nucleotide additions (Aravin and Tuschl 2005; Landgraf et al. 2007).”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “The miRNAs with promoters bound by Polycomb group proteins in ES cells were significantly enriched (p 0.005) among the set of the most tissue-specific mammalian miRNAs (Figure S10 and Landgraf et al., 2007).”
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. (2011, background): “MiRNA122 (miR122) is a tissue-specific miRNA that is most abundant in the live”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, background): “Importantly, in the AGO PAR-CLIP library, the majority of miRNA sequence reads derived from prototypical miRNAs (Landgraf et al., 2007) displayed T to C conversion near or above 50%.”
The Role of MicroRNAs in Human Diseases (2010, background): “Many miRNAs are expressed in a tissue-cell-specific manner (73) and in adult cardiac tissue, miR-1, miR-16, miR-27b, miR-30d, miR-126, miR-133, miR-143, and the let-7 family are abundantly expressed (74) .”
An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “…cells to sites of ischemia and their contribution to cardiac repair (Kocher et al., 2001; Takahashi et al., 1999). miR-126 is expressed in hematopoietic stem cells, and might therefore contribute to the regenerative functions of this cell population (Garzon et al., 2006; Landgraf et al., 2007).”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, methodology): “miRNA genomic clusters were defined taking into consideration EST evidence and levels of miRNA expression from our data (22).”