mir-29 regulates Mcl-1 protein expression and apoptosis

By J. Mott, Shogo Kobayashi, S. Bronk, G. Gores. Oncogene, 2007

879 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/86d3150d57431e43f5d2b2f0e668db2c005b8b22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

MicroRNA and cancer (2012, background): “Furthermore, miR-29b is a regulator of the anti-apoptotic protein Mcl-1, which is upregulated in malignant cells in which miR-29b is concurrently downregulated (Mott et al., 2007).”
Reprogramming of miRNA networks in cancer and leukemia. (2010, background): “2009), hsa-miR-29a/b in breast, colon, and lung cancers (Mott et al. 2007; Gebeshuber et al. 2009), hsa-miR-181 family members in colon and breast cancers (Spizzo et al.”
Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis (2011, background): “Recently, an involvement of miRNAs was demonstrated in highly regulated processes such as hepatocyte apoptosis and hepatocarcinogenesis.(5,6) Furthermore, expression of miR122 correlates with response to interferon treatment of patients infected with hepatitis C virus.”
Bcl-2 family proteins and cancer (2008, background): “Loss of miR-29, which represses antiapoptotic family member MCL-1, can occur in chronic lymphocytic leukemia and colon cancers (Calin et al., 2005; Cummins et al., 2006; Mott et al., 2007), suggesting at least one responsible mechanism for elevated expression of relatives of BCL-2.”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “…methylation in NSCLC and reduces tumorigenicity in vitro and in vivo Increases apoptosis sensitivity to TRAIL TCL1 and Mcl-1 Fabbri et al. (2007); Mott et al. (2007); Pekarsky et al. (2006) miR-34a p53 inducible; translationally regulates cell cycle, anti-apoptotic and check point genes; shown…”
MicroRNAs in cancer: small molecules with a huge impact. (2009, background): “Members of the miR-29 family have been shown to be downregulated in aggressive CLL,(6) invasive breast cancer,(18) lung cancer,(40) and cholangiocarcinoma.(8) Transfection of miR29b induces apoptosis in cholangiocarcinoma cell lines and reduces the tumorigenicity of lung cancer cells in nude mice.”
MiR-15a and miR-16-1 cluster functions in human leukemia (2008, background): “Interestingly, miR-29b has also been identified to target Mcl1 in a cholangiocarcinoma model (39), and many pieces of evidence converge in defining a role of the miR-29 family as TSGs in both solid (40) and hematologic malignancies (41).”