Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function.

By Ken C. Pang, Martin C. Frith, John S. Mattick. Trends in Genetics, 2006

662 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e833b402b1128ce278a48eeaa2205bd636c40927

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Citations in the corpus

Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities (2008, background): “, changes that do not result in amino acid substitution) over non-synonymous ones, but are limited by the numbers of genomes available for comparison and the rapid evolution of many ncRNAs [33], making it difficult to detect orthologous sequences.”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “This limits the availability of cellular and animal models for investigation of lncRNA functions, even though lncRNAs differing from each other in their nucleotide composition can still show the same three-dimensional structure, and therefore, the same molecular function (60, 217).”
Long non-coding RNAs: insights into functions (2009, background): “Indeed, many long ncRNAs with a known function, such as Xist , only exhibit high conservation over short sections of their lengt”
Long Non-coding RNAs in the Cytoplasm (2016, background): “gadd7 is not highly conserved at the nucleotide level [29,30].”
On the classification of long non-coding RNAs (2013, background): “16 However, lncRNAs are poorly conserved among different species when compared with the well-studied RNAs (such as mRNAs, miRNAs, snoRNAs), 4,17,18 invoking uncertainty about whether a given lncRNA is functional at all due to poor interspecies conservation, or it conveys functional species-specific…”
The Genetic Signatures of Noncoding RNAs (2009, background): “While many ncRNAs, like other regulatory sequences (see below), appear to be evolving quickly, including those with well-validated functions [26], most retain conserved patches within them [26,32], and some may be under positive selection, especially in the brain [57].”
Non-coding RNA. (2006, background): “Consistent with this, the known miRNAs appear to have many targets, thereby making co-variation difficult, and explaining their strong conservation, which in many cases surpasses that of protein-coding sequences (108).”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, result): “Although many ncRNAs evolve quickly and may be lineage-specific (Pang et al. 2006), the observed prevalence of positional equivalents is similar to that seen in previous studies (Engstrom et al.”
The rise of regulatory RNA (2014, background): “Indeed there is now considerable evidence that lack of primary sequence conservation in lncRNAs does not indicate lack of function 190,191 , and that many lncRNAs show evidence of structural conservation 192,193 .”
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. (2007, background): “Others have argued that an apparent lack of sequence conservation need not imply an absence of function if positive, rather than negative, selection has prevailed (Pang et al. 2006).”
The Role of MicroRNAs in Human Diseases (2010, background): “Such specific functions are thought to limit sequence co-variation and tendency to evolution ((16)).”
Large-scale prediction of long non-coding RNA functions in a coding–non-coding gene co-expression network (2011, background): “Generally, lncRNAs are as poorly conserved as the introns of coding genes and less conserved than the 50- or 30-untranslated regions (UTRs) of mRNAs (8).”
Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci (2016, background): “There are other indications as to what some of these differing constraints may be, including the early observation that lncRNAs can have promoters that exhibit higher conservation and that extends to longer sequence stretches than observed for promoters of coding genes (Carninci et al., 2005).”
Evolution and functions of long noncoding RNAs. (2009, background): “Another interpretation of the frequently low sequence conservation of noncoding RNAs is that they may be frequently acted upon by positive selection (Hyashizaki, 2004; Pang et al., 2006).”