On the classification of long non-coding RNAs

By Lina Ma, Vladimir B. Bajic, Zhang Zhang. RNA Biology, 2013

1,147 citations recorded by the source corpus.

Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups. Here, we summarize classification methods of lncRNAs according to their four major features, namely, genomic location and context, effect exerted on DNA sequences, mechanism of functioning and their targeting mechanism. In combination with the presently available function annotations, we explore potential relationships between different classification categories, and generalize and compare biological features of different lncRNAs within each category. Finally, we present our view on potential further studies. We believe that the classifications of lncRNAs as indicated above are of fundamental importance for lncRNA studies, helpful for further investigation of specific lncRNAs, for formulation of new hypothesis based on different features of lncRNA and for exploration of the underlying lncRNA functional mechanisms.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e516f845e1888d981b2382ab2bca6e84bb48d26

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Subhrangsu S. Mandal
2. Milad Soleimani
3. A. Bhan

In Molecular Biology

1. Subhrangsu S. Mandal
2. Milad Soleimani
3. A. Bhan

Citations in the corpus

• Long non-coding RNA (LncRNA) and cancer: a new paradigm (2017, background): “Examples of guide lncRNAs include AIR, CCND1 (cyclin D promoter associated lncRNA), lincRNAp21, and others (8, 9).”