Long non-coding RNAs: insights into functions

By Tim R. Mercer, Marcel E. Dinger, John S. Mattick. Nature reviews genetics, 2009

5,575 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c008a5237dae66f5bb12bbf365584f3561f94837

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Citations in the corpus

Braveheart, a long non-coding RNA required for cardiovascular lineage commitment (2013, background): “…that are 50 capped and polyadenylated like most mRNAs, yet this class of transcripts has limited coding potential. lncRNAs function in a wide range of processes and can regulate gene expression by diversemechanisms (Hu et al., 2012; Mercer et al., 2009; Ponting et al., 2009; Rinn and Chang, 2012).”
The rise of regulatory RNA (2014, background): “Long noncoding RNAs (lncRNAs) are operationally defined as any non-protein-coding RNA >200 nt in length, which corresponds to a convenient cut-off in biochemical fractionation and excludes all known classes of small RNAs 172 .”
Peptidomic discovery of short open reading frame-encoded peptides in human cells (2012, neutral): “Another intriguing feature of these experiments was the discovery of SEPs encoded by lincRNAs. lincRNAs have emerged as an important class of regulatory molecules with intrinsic biological functions (e.g., hotair, xist) 41, 42 .”
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation (2010, background): “Recent studies have revealed the existence of many lncRNAs in cells (Mercer et al., 2009; Wilusz et al., 2009).”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “Proteins are considered to be the main protagonists of cellular functions, while RNA is considered to be merely an intermediary between genes and proteins [1,2].”
LncRNA-mediated regulation of cell signaling in cancer (2017, background): “For example, lncRNAs may serve as signals to promote transcription, or as decoys to repress transcription, or as epigenetic regulators, or as scaffolds to interact with various protein partners to form ribonucleoprotein complexes (Mercer et al 2009, Ulitsky and Bartel 2013, Wang and Chang 2011).”
Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions (2011, background): “…RNAs are key regulators of chromatin states for important biological processes such as dosage compensation, imprinting, and developmental gene expression (Kelley et al., 1999; Koziol and Rinn, 2010; Mercer et al., 2009; Pandey et al., 2008; Rinn et al., 2007; Wang et al., 2011; Zhao et al., 2008).”
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, neutral): “Interestingly, they are also emerging as recruiters of PcG proteins to target gene”