Evolution and functions of long noncoding RNAs.

By Chris P. Ponting, P. Oliver, Wolf Reik. Cell, 2009

4,858 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e024ee20365a4bb64ec5fed3d4678c5b0da7a701

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Citations in the corpus

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (2012, background): “lncRNAs are broadly defined as expressed RNAs of more than 200 nt in length that lack obvious protein-coding capacit”
FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome (2017, methodology): “The shuf-fle strategy employs a more sophisticated method which is based on the idea that lncRNAs are derived from ‘debris’ of protein-coding genes (41,42), as exemplified by the Xist lncRNA that emerged from the disruption of the mRNA gene Lnx3 (43).”
The functional role of long non-coding RNA in human carcinomas (2011, background): “Although initially argued to be spurious transcriptional noise, recent evidence suggests that the proverbial “dark matter” of the genome may play a major biological role in cellular development and metabolism [11-17].”
LncTar: a tool for predicting the RNA targets of long noncoding RNAs (2015, neutral): “LncRNAs are generally defined as noncoding RNA molecules >200 nucleotides (nt) in length [5].”
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. (2010, background): “Besides providing the primary transcript for the production of miR15a/16-1, it produces a spliced cytoplasmic RNA (data not shown) that, analogous to other long sterile transcripts (Ponting et al., 2009), may have important regulatory functions not detected by the in vitro assays used here.”
Long non-coding RNAs with enhancer-like function in human (2010, result): “These results are in concordance with previous observations in the mouse genome (Guttman et al., 2009; Ponting et al., 2009).”
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. (2011, background): “This possibility was previously raised (Mercer et al. 2009; Ponting et al. 2009) based on differential expression patterns in specific biological systems and has several implications.”
NONCODEV5: a comprehensive annotation database for long non-coding RNAs (2017, background): “Most genomic transcripts are noncoding, whereas only a small fraction of the transcripts encode proteins (2,23).”
Transcriptional control of the inflammatory response (2009, background): “Broadly speaking, lncRNAs have been described that direct the expression of specific genomic loci (regulation in trans ); alternatively, the process rather than the product of lncRNA transcription has been shown to inhibit or activate gene expression (regulation in cis”
lincRNAs: Genomics, Evolution, and Mechanisms (2013, positive): “New lincRNA genes might originate from either ancestral protein-coding genes; duplication and divergence of other lincRNA genes; or de novo, from intergenic DNA (Ponting et al., 2009).”
Epigenetics and gene expression (2010, background): “An initial concern was that lncRNAs represent ‘loose’ or ‘noisy’ transcription (Mattick, 2005; Struhl, 2007; Ponting et al., 2009) and/or artefacts of experimental procedures (e.”