Plasmacytoid dendritic cells in immunity

By M. Colonna, G. Trinchieri, Yong‐jun Liu. Nature Immunology, 2004

1,843 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e75d046dd96d019aa0dc2e31de06a61f53858891

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Citations in the corpus

Immunosuppressive networks in the tumour environment and their therapeutic relevance (2005, background): “Human DCs are traditionally divided into two main populations: MYELOID DCs and PLASMACYTOID DCs”
The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Two principal populations of DC exist in mouse and human tissues: myeloid DC (MDC) and plasmacytoid DC (PDC), which are derived from HSC progenitor”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “It has been well established for some time that in addition to TLR3 and TLR4 activation, TLR7 and TLR9 activation also triggers IFN production in pDCs, a subset of DCs specialized in producing large amounts of type I IFN in response to virus infection (59).”
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “For example, pDCs are unique in that they constitutively express the transcription factor IRF7 allowing them to quickly produce high levels of type I IFNs in response to viral infection while other cell types such as macrophages may respond in a more delayed manner [2,3].”
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. (2005, background): “Whereas other APCs provide proinflammatory instructions during infection, DCs uniquely signal protective and tolerance-inducing reactions by T cells (Colonna et al., 2004).”
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity (2005, background): “Notably, plasmacytoid DCs are thought to be involved in tolerogenic functions through generation of regulatory T cell”
Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand (2007, background): “20061660 105 Myeloid DCs (mDCs) and plasmacytoid preDCs (pDCs) represent two major subsets of DCs in humans (1, 2).”
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, background): “For example, human myeloid and plasmacytoid dendritic cells (MDC and PDC) respond strongly but quite differently to single-stranded RNA viruse”
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “CD8 + lymphoid DCs and plasmacytoid DCs (pDCs) are two important types of DC that are essentially restricted to lymphoid organ”
A critical function for type I interferons in cancer immunoediting (2005, background): “, a specialized subset of leukocytes known as interferon-producing cells produce particularly large amounts of IFN-α/β during viral challeng”
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors (2005, neutral): “In contrast, the induction of IFN-α, which is exclusive to plasmacytoid dendritic cells stimulated by CpG-A OD”
Toll-like receptor function and signaling. (2006, background): “Several studies indicate that TLR activation leading to type I IFNs contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE).(33) In SLE antinuclear antibodies are produced and nuclear proteins are released from damaged or inflamed tissues.”
Evasion of intracellular host defence by hepatitis C virus (2005, background): “Because dendritic cells represent a major source of IFN production during viral infection, modulation of their function may influence systemic and/or local IFN signalling and ISG expressio”