Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

By H. Polson, J. de Lartigue, Daniel J. Rigden, M. Reedijk, S. Urbé, M. J. Clague, S. Tooze. Autophagy, 2010

703 citations recorded by the source corpus.

Subfields: Biochemistry, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/790ad48e398a3efbc9d6068c0ee0745b61782d8e

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Citations in the corpus

An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Mammalian cells express two Atg18 orthologs, WIPI1 and WIPI2, which are also involved in macroautophagy and associate with phagophores during amino acid starvation by binding to PtdIns3P (60, 118, 119).”
Autophagy and autophagy-related proteins in cancer (2020, background): “The WIPI1/2-ATG2 (Atg18-Atg2 in yeast) complex localizes to the expanding edge of the isolation membrane and plays a key role in the elongation and/or closure of the isolation membrane [43, 142] (Fig.”
Selective autophagy mediated by autophagic adapter proteins (2011, background): “The WIPI (WD-repeat protein interacting with phosphoinositides) family proteins, notably WIPI1 and WIPI2, are Atg18 homologues acting in early steps of autophagosome formation.(9,10) Finally, the ATG9 transmembrane protein is involved in membrane trafficking and is required for autophagy, but its fu”
Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes (2016, background): “For example, the mammalian-specific protein ZFYVE1, a member of the PTHR22835 family, plays an important role in the early step of autophagosome formation and is used as a marker for omegasomes (38).”
Autophagy and the integrated stress response (2010, positive): “, 2008) and WD-repeat protein interacting with phosphoinositides (WIPI) family proteins (Polson et al., 2010) to mediate the initial stages of vesicle nucleation/autophagosome formation.”
Molecular definitions of autophagy and related processes (2017, positive): “This enables the association of the PI3P-binding proteins DFCP1 and WIPI2 (Polson et al , 2010), the formation of ATG12-ATG5:ATG16L1 complexes, and consequent local LC3 lipidation (Dooley et al , 2014).”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “ZFYVE1 partially colocalizes with WIPI1 upon nutrient starvation,421 and also with WIPI2.”
Autophagy in immunity and inflammation (2011, background): “Among the four WIPI isoforms, WIPI2 is the major form in most cell types and functions downstream of DFCP1, and it may promote the development of omegasomes into isolation membranes or autophagosomes 16 .”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “LAMP2-positive autophagosomes or autolysosomes using immunolabeling.(559) Accordingly, it may be possible to follow the formation and subsequent disappearance of WIPI puncta to monitor”